Acetylcholinesterase info (nightshade sensitivity)

[Highserotonin90]

@youngsinatra Correct clarification, thanks!

 

[moa]

Copper only degrades histamine in the digestive tract, from food sources. (via DAO)
Methylation (SAMe) degrades intracellular histamine. (via HNMT)

hnmt intracellular histamine - Google Suche

Copper is also the main factor to reducing intracellular histamine, as HNMT is a copper enzyme too.

adequate copper levels are necessary for the synthesis of dopamine and norepinephrine in the brain. norepinephrine is needed to balance high acetylcholine in the autonomous nervous system.

Taking too much zinc can inhibit copper too.

 

[AinmAnseo]

Glycoalkaloids are found throughout the potato tubers, but concentrate in the sprouts, peel and the area around the potato ‘eyes' (Figure 2). In normal tubers, glycoalkaloids are concentrated in a small 1.5 mm layer immediately under the skin (i.e. 30 to 80% of the glycoalkaloids are found in the outer peel). According to a study conducted by the CFS in 2007, the glycoalkaloid content (alpha-solanine and alpha-chaconine) of five cultivars of tubers available in the Hong Kong market ranged from 26 to 88 mg/kg fresh weight. While glycoalkaloids were below 10 mg/kg in the flesh of these potatoes, glycoalkaloids in the peel varied between 90 and 400 mg/kg. Peeling of potatoes will greatly reduce the levels of glycoalkaloids present.

Toxic Glycoalkaloids in Potatoes

 

[FitnessMike]

Thyroid, coffee and low-dose biotin are the only things that seems to help. And avoiding pro-cholinergic substances/foods (B vitamins usually bite me in the **** after a few days)

Do you think that elevated ach could further impair metabolism in people like us?

 

[youngsinatra]

Do you think that elevated ach could further impair metabolism in people like us?

Acetylcholine in excess can raise nitric oxide (NO), which can react with oxygen and create peroxynitrite (ONOO) which then *irreversibly* inhibits oxidative phosphorylation and many enzymes in energy metabolism. I think lowering NO might help.

You can find lots of interesting stuff on "nitrosative stress" and how its implicated in a lot of diseases.

 

[Sampj97]

Thanks!

Yeah zinc and copper involvement with AChE is not necessarily conclusive. Here is one study: "A dietary control study demonstrated that the reduction in plasma cholinesterase activities observed in zinc deficient rats was not due to reduced food intake. Instantaneous and time-dependent inhibition studies with various chelating agents were subsequently conducted on the activities of various cholinesterase enzymes (eel AChE, recombinant human AChE, horse serum BChE, and rat plasma cholinesterases). Plasma BChE was found to be substantially inhibited by 1,10-phenanthroline, but only mildly by the non-chelating analog, 4,7-phenanthroline, further suggesting that it may be a zinc metalloenzyme. In conclusion, zinc is a physiological modulator of Butyrylcholinesterase."

But this study found this: "Zinc deficiency resulted in the significant increase of blood Ach and 5-HT,and brain 5HT"

And another: "However, the effects of zinc and copper on the AChE activity are little known and sometimes contradictory. The brain enzyme of fish is inhibited by zinc (Suresh et al. 1992) and activated by copper (Romani et al., 2003). The brain AChE of rats may be either decreased (Brocardo et al., 2005) or increased by zinc (Carageorgiou et al., 2005) and increased by cadmium (Carageorgiou et al., 2005)."
"In conclusion, although the simultaneous administration of zinc and copper caused a decrease in the body weight gain, these metals separately did not alter the cerebral and corporal development. Zinc and copper treatment did not change the cerebral AChE activity and zinc and copper contents; whereas in vitro high concentrations of copper decreased the cerebrum and cerebellum AChE activity. Despite the in vitro results, the absence of in vivo effects permits to suggest that copper may be investigated as a possible preventive essential metal to toxic effects of the heavy metals as observed to zinc (Peixoto et al. 2003, 2008; Peixoto and Pereira 2007; Franciscato et al., 2009)"

I still haven't decided on the copper!

But vitamin C has absolutely been helpful for neurotransmitters. I hope others will also see that thiamine is acetylcholine promoting which is great for those with severe brain fog and memory issues, but very unlikely to be helpful for those with an overstimulated brain.
What was the connection with vitamin E and acetylcholine?
What do you think about the nightshade stuff?

I'm really considering this AChE and BChE to be an underlying reason why people are doing very well on a low vitamin A diet which also decreases the highest sources of choline in the diet such as eggs and liver, and reduces plant toxins from things like tomatoes and peppers. All the case studies I've seen on vitamin A toxicity symptoms resolved quite quickly. But a sensitivity to acetylcholine might never go away.

What about retinyl ESTERS, does eliminating those affect the enzyme?

 

[Nimo]

Does someone know, if blood test of acetylcholinesterase is worth it? if someone is eating alot potatoes, and have some symptoms, it should show in blood as low AchE?