Shai Hulud
Member
- Joined
- Jan 29, 2018
- Messages
- 21
I'm reacting very strangely to glycine.
Even at 1 g I will feel fatigued and very unsharp mentally the next day, but more like several days, slowly getting better. Also lowered mood and getting out of bed harder than usually (=very hard)
Taking Vitamin A palmitate once at 15,000 IU felt very similar, so this could be related.
On the other hand, I take TMG and have tried up to 8 g a day and get no problems. I'm homozygous for MTHFR C677T.
Did a dutch test last year and thyroid (TSH/T4/T3/antibodies). Thyroid was ok, cortisol seemed ok, but sex hormones were super high, especially estradiol.
Did an additional testing of SHBG and total testosterone, both again really high.
Also tracking my food intake, seeing that I don't consume enough glycine, especially since I probably loose a lot through my glycine buffer system (low 5-MTHF).
When I had the hormones tested (late in summer '17), I had also done an OAT test by great plains and it showed low 5-HT metabolites.
@haidut Can you help me out here? What is happening?
Even at 1 g I will feel fatigued and very unsharp mentally the next day, but more like several days, slowly getting better. Also lowered mood and getting out of bed harder than usually (=very hard)
Taking Vitamin A palmitate once at 15,000 IU felt very similar, so this could be related.
On the other hand, I take TMG and have tried up to 8 g a day and get no problems. I'm homozygous for MTHFR C677T.
Did a dutch test last year and thyroid (TSH/T4/T3/antibodies). Thyroid was ok, cortisol seemed ok, but sex hormones were super high, especially estradiol.
Did an additional testing of SHBG and total testosterone, both again really high.
Also tracking my food intake, seeing that I don't consume enough glycine, especially since I probably loose a lot through my glycine buffer system (low 5-MTHF).
When I had the hormones tested (late in summer '17), I had also done an OAT test by great plains and it showed low 5-HT metabolites.
@haidut Can you help me out here? What is happening?
I have long suspected that inhibitory amino acids suppress cortisol release. The reason is that most of these inhibitory amino acids like glycine, taurine, beta alanine, theanine, etc are all GABA agonists. GABA agonist pharma drugs are used to treat Cushing syndrome and are very effective at lowering cortisol. However, up until today I did not have much evidence for such an effect of amino acids with the possible exception of theanine.
This study shows that glycine can acutely lower cortisol to about 20% of controls (i.e. 80% reduction). The study was done in chickens, so unfortunately the dosage conversion is a bit difficult to come buy but I think the results are valid given that glycine has also been shown to stop aging-related muscle loss and even cancer cachexia, both of which are mediated at least partially through elevated cortisol. So, if somebody knows how to convert doses from chicken to rodent or human please chime in. I have included a link that talks about doses of specific drugs for rodents, pigs, cats, dogs and birds and based on that conversion it looks like the effective dose in humans to achieve the cortisol-lowering effect could be as low as 70mg/kg. This dose is surprisingly close to the 1mmol/kg (75mg/kg) glycine that acutely lowered the glycemic response in humans by more than 66% without changing insulin levels. As you can see from the screenshot, glycine also lowered cortisol in chickens without changing insulin. In general, anything that lowers cortisol will lower blood sugar, so it is quite plausible that the cortisol-lowering effects of glycine are behind its beneficial effects on blood glucose, diabetes, obesity, bone health, and aging which I have posted about in separate threads on this forum.
Effects of orally administered glycine on myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle in chicks. - PubMed - NCBI
"...The plasma corticosterone concentration was also decreased by glycine, but the plasma insulin concentration was unaffected. These results indicate that orally administered glycine suppresses myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle by decreasing the plasma corticosterone concentration in chicks."
The domestic animals drug conversion link:
Veterinary Formulary
Another substance that also powerfully lowers cortisol is niacinamide and thus can synergize well with glycine to block the stress response.
Niacinamide Lowers Cortisol | Ray Peat Forum