Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
I'm not sure if this study has been posted before , at least I haven found anything under the "DHEA" tag.
Anyways, it's always good to have more in vivo evidence for peaty substances and what they do in real life.
This study gave aging men with partial androgen deficiency (58-69)the "low dose" of 25mg DHEA for one year.
First of all the scores for tiredness , depression amd joint pain were less then half of what they were before the DHEA treatment.
So they also subjectively felt a difference .
The hormonal values are also very interesting:
DHEA : tripled
DHEA-S : quadrupled
TESTOSTERONE (total): almost doubled
TESTOSTERONE FREE: more than doubled
DHT: doubled
PROG: doubled
ALLOPREGNANOLONE: almost doubled
ANDROSTENEDIONE: almost doubled
17ohP : doubled
SHBG : slightly decreased
E1: doubled
E2 : more than doubled
LH+FSH: slightly decreased
CORTISOL :stayed the same
GH: more than doubled
It increases all beneficial hormones across the board , so I'm not surprised the men also subjectively felt a lot better .
The increase in estrogen is worrisome, although estrogen antagonists like progesterone, dht and allopregnanolone also increased just as much , so the rise in estrogen isn't unopposed.
To some degree the increase in E Will be because of increased T (aromatization) ,but I suspect the biggest part is from the large dosage . Since DHEA is known to be converted into estrogen in dosages above 5mg . So I'd suspect less estrogen and similar androgen increase if they kept the dosage lower .
Also noteworthy is the gradual increase in steroids. From months 0-6 there was a gradual increase in those hormones ,from 6-12 the increase was very little .
So if someone does an experiment with it , it might be worth to wait 6 months until you get a blood test , to see DHEAs full effects .
Anyways, it's always good to have more in vivo evidence for peaty substances and what they do in real life.
This study gave aging men with partial androgen deficiency (58-69)the "low dose" of 25mg DHEA for one year.
First of all the scores for tiredness , depression amd joint pain were less then half of what they were before the DHEA treatment.
So they also subjectively felt a difference .
The hormonal values are also very interesting:
DHEA : tripled
DHEA-S : quadrupled
TESTOSTERONE (total): almost doubled
TESTOSTERONE FREE: more than doubled
DHT: doubled
PROG: doubled
ALLOPREGNANOLONE: almost doubled
ANDROSTENEDIONE: almost doubled
17ohP : doubled
SHBG : slightly decreased
E1: doubled
E2 : more than doubled
LH+FSH: slightly decreased
CORTISOL :stayed the same
GH: more than doubled
It increases all beneficial hormones across the board , so I'm not surprised the men also subjectively felt a lot better .
The increase in estrogen is worrisome, although estrogen antagonists like progesterone, dht and allopregnanolone also increased just as much , so the rise in estrogen isn't unopposed.
To some degree the increase in E Will be because of increased T (aromatization) ,but I suspect the biggest part is from the large dosage . Since DHEA is known to be converted into estrogen in dosages above 5mg . So I'd suspect less estrogen and similar androgen increase if they kept the dosage lower .
Also noteworthy is the gradual increase in steroids. From months 0-6 there was a gradual increase in those hormones ,from 6-12 the increase was very little .
So if someone does an experiment with it , it might be worth to wait 6 months until you get a blood test , to see DHEAs full effects .
Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency - PubMed
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) age-related withdrawal is very likely to be involved in the aging process and the onset of age-related diseases, giving rise to the question of whether preventing or compensating the decline of these steroids may have...
pubmed.ncbi.nlm.nih.gov
Last edited: