Hey Gabor, @gerdosi
- so OP (@thepowerofozone
) may be on a different hypothesis, but a lot of us are subscribers to a new paradigm of health and disease called Toxic Bile Theory.
Here's my breakdown:
This theory's name was coined by @NutriDetect
, but the idea was originally pioneered by a researcher named Anthony Mawson who has several papers connecting it to modern diseases, from flu to glioma to gulf war syndrome to rubella to the disease state known as "COVID".
In general, toxic bile theory states that when the liver becomes cholestatic, the bile ducts become damaged and the bile begins to "spill over" into the blood stream. This liver damage is often (but not always) caused by excess retinol stores, but can also be from copper toxicity, vaccine damage, and probably a ton of other things I'd argue like excess fructose and/or seed oil metabolites (toxic aldehydes).
Here are a few Mawson papers, but he's got a ton more:
https://ncbi.nlm.nih.gov/pmc/articles/PMC8392079/ (Corona)
https://ncbi.nlm.nih.gov/pmc/articles/PMC7712358/ (Vax damage)
https://ncbi.nlm.nih.gov/pmc/articles/PMC6801530/ (Rubella)
https://ncbi.nlm.nih.gov/pmc/articles/PMC6339135/ (Gulf War Illness)
Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective (Flu)
Certain events can put this into overdrive, causing nasty disease bouts.
The key feature, however, is that the bile that enters the bloodstream is not just containing retinol -- it contains unbound retinyl esters and retinoic acids. Retinol, bound by RBP-4 (Retinol Binding Protein 4), is relatively harmless. But retinyl esters are anything but -- they're quite damaging, and this has been known for 50 years:
Interestingly, those retinyl esters are bound to... low density lipoproteins -- yes, LDL! This is something nobody in the cholesterol community talks about, but is a big reason why high LDL can be connected to disease states
This can take you down the vitamin A rabbit hole, which is easily summarized as such:
1. Fat soluble class of molecules
2. Accumulate in the liver
3. Toxic in excess
4. Difficult to metabolize and excrete
5. The acid metabolites are far more toxic than the retinol itself
While retinol itself is harmless when bound to RBP-4, the issue occurs when that system breaks, either due to:
1. Overloaded liver that breaks down
2. Low protein, zinc, and possibly taurine
You'd think that measuring serum retinol would be a great biomarker, but when the liver becomes damaged by either of the above two situations, it actually can't generate RBP-4, and the retinol gets stuck in the liver and isn't in serum.
As an example, researchers can often FIX "vitamin A deficiency" merely by providing protein and calories without any added vitamin A:
So you can be in de-facto Hypervitaminosis A and have LOW serum retinol levels! But you'll get the nasty spillover of retinyl esters and retinoic acids. You can connect this situation with the majority of modern diseases, especially all of the skin conditions, diabetes, insulin resistance, and all the crap you see on American TV ads.
What Tucker linked to when I got sick this winter (an "overdrive" situation), it literally felt like I had every symptom of hypervitaminosis A. But that's crazy -- I was on a low vitamin A diet for over a year, how is that possible? Well, after 12 months of the diet, I *still* had absurdly high serum retinol numbers. What we're realizing is that we've got YEARS of this crap built into our livers. And sometimes, the liver seems to let it rip.
Maybe vitamin A is essential, some in this community argue it's not... but too many of us in the west have definitely met our quota through formula, milk/cereal fortification, medications, toxicity passed down from mom, and poor dietary decisions. As I undo that, I feel better and better each month.
So anyway, if this theory is in fact true (and I think it's the closest thing to the truth that we've got), the better lab test to determine subclinical and clinical vitamin A toxicity is to look at the ratio of serum retinyl esters to serum retinol. If it's over 5%, you're in trouble.
But, guess what -- such a test isn't commercially available. Isn't that crazy?!
This whole thing can simultaneously fix a crapload of disease and blow open the LDL debate. It's wild.
Until then, I'm treating it like a marathon, not a sprint. I'll let you know when I become "vitamin A deficient" and if I go blind. My bet is that I do not, because I'm eating tons of protein and zinc. Also, don't believe the USDA, there's plenty of retinol in beef. So I'm not even on that low of a vitamin A diet. I'm normal, everyone else is just getting absurd amounts.
That's my take -- toxic bile theory is the missing glue for many of these "diet war" folks, and more will fold it into their hypotheses over time. Happy to send more research or answer questions.
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