In yet another winning day (as Trump likes to say) for niacinamide, this study shows that the metastatic process of breast cancer is controlled by the NAD/NADH ratio, and NAD precursors like niacinamide can be effective chemotherapeutic agents. The human equivalent dose was 3g - 3.5g daily for a few weeks. I supposed we can add this study to the ones I posted about the tetracyclines, and other potentially therapeutic agents.
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. - PubMed - NCBI
"...The reported weights include all fat pads of each mouse, regardless of tumor presence. Importantly, histopathological analysis revealed that NAM treatment drastically inhibited breast cancer progression (Figure (Figure8,8, C and D, and Supplemental Figure 18). All untreated MMTV-PyMT mice had tumors primarily containing adenoma, early and advanced carcinoma, and little normal and hyperplastic tissue. In contrast, NAM-treated mice had normal mammary fat pads; tumors, if found, were small and consisted predominantly of hyperplastic and adenoma tissue. Furthermore, whereas lung metastases were detected in 4 of 7 untreated animals, no metastases were found in NAM-treated MMTV-PyMT mice (0 of 6), as assessed by comprehensive histology in serial lung sections (data not shown). Importantly, NAM treatment induced autophagy in PyMT mammary tumors in vivo, as shown by p62 degradation in Western blot analyses of individual tumors (Figure (Figure8E8E and Supplemental Figure 19). We did not detect effects on mTORC1 activity regulation, which suggests that NAM treatment in the drinking water might transiently modulate mTORC1 activity within PyMT mammary tumors in vivo.
In another thread I posted a human case study showing that a hefty dose of niacinamide (4g) elevated NAD levels more than 20 fold and brought lactate back to normal.
Niacinamide Causes Dramatic Increase In Nad And Fall In Lactate | Ray Peat Forum
This certainly plays is one of the major mechanisms behind the anti-metastatic effects of niacinamide reported above.
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. - PubMed - NCBI
"...The reported weights include all fat pads of each mouse, regardless of tumor presence. Importantly, histopathological analysis revealed that NAM treatment drastically inhibited breast cancer progression (Figure (Figure8,8, C and D, and Supplemental Figure 18). All untreated MMTV-PyMT mice had tumors primarily containing adenoma, early and advanced carcinoma, and little normal and hyperplastic tissue. In contrast, NAM-treated mice had normal mammary fat pads; tumors, if found, were small and consisted predominantly of hyperplastic and adenoma tissue. Furthermore, whereas lung metastases were detected in 4 of 7 untreated animals, no metastases were found in NAM-treated MMTV-PyMT mice (0 of 6), as assessed by comprehensive histology in serial lung sections (data not shown). Importantly, NAM treatment induced autophagy in PyMT mammary tumors in vivo, as shown by p62 degradation in Western blot analyses of individual tumors (Figure (Figure8E8E and Supplemental Figure 19). We did not detect effects on mTORC1 activity regulation, which suggests that NAM treatment in the drinking water might transiently modulate mTORC1 activity within PyMT mammary tumors in vivo.
In another thread I posted a human case study showing that a hefty dose of niacinamide (4g) elevated NAD levels more than 20 fold and brought lactate back to normal.
Niacinamide Causes Dramatic Increase In Nad And Fall In Lactate | Ray Peat Forum
This certainly plays is one of the major mechanisms behind the anti-metastatic effects of niacinamide reported above.
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