TreasureVibe
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Potassium ascorbate is a salt derived from vitamin C that is totally non-toxic and free from side effects.
The compound can be extemporaneously (i.e. without any preparation) obtained by dissolving ascorbic acid (150 mg) and potassium bicarbonate (300 mg of which 117 mg potassium) in water. It has a pH level that tends to neutralize in less than a minute. The two components have to be dissolved in 20 cc water (about two fingers high) without using a metallic spoon (because of the potential risk of oxidation of the ascorbic acid).
Potassium ascorbate is related to the studies and research of the Florentine biochemist Dr. Gianfrancesco Valsè Pantellini and its ‘story’ starts in 1948 when a goldsmith and friend of Dr. Pantellini, affected with inoperable stomach cancer, experiences unexpectedly and absolutely extraordinary results after taking lemon juice in which he accidentally dissolved potassium bicarbonate instead of sodium bicarbonate. Pantellini studied and analyzed this subject for about twenty years, leading to two specific publications in 1970 and 1974 in the Journal of Medical Pathology.
Oxidative processes linked to the presence of free radicals are involved in the impetus and development of cancer. Free radicals (substances with a high chemical reactivity) are the main reason for the mechanism of oxidative stress. Living organisms tend to maintain a constant level of the concentration of these oxidizing agents to ensure normal biological processes.
Based on the studies of Dr. Pantellini, we are convinced that oxidative stress damages cell membrane structures, in particular the sodium-potassium ATPase (also known as the Na/K pump). This causes (an initially mild) depolarization and an increasingly greater alteration of the active transport mechanism of these two electrolytes, that have very different but fundamental functions in the cellular organization; potassium is the main regulator of intracellular metabolic processes through reversible salification of amino groups and imino of enzymes and proteins in a slightly acid environment; the other, sodium, is the main regulator of the alkaline reserve of the organism at extracellular level, with reversible salification of carboxylic groups of enzymes and proteins in a more or less basic environment.
In this way we obtain an increasingly bigger modification of the acid-based environment and redox-reactions between cytoplasmic molecules.
We are convinced that this fact constitutes the activating mechanism (trigger) for mutation into a cancerogene cell. In fact, research relating to the sarcoma (malignant tumor) of Rous that was already published in the 30′s (Moraveck and Kishi) proved that the neoplastic cell is lacking potassium and rich of sodium, with an increasingly greater imbalance along with the development of cell degeneration.
This seems to be the common denominator in all neoplastic diseases and is also verifiable through a careful evaluation of the four hematic electrolytes (sodium, calcium, potassium, magnesium) in the blood.
The described mechanism turns out to be very dangerous for the cell when:
These processes lead to a modification in cell respiration, with a decrease of oxidative phosphorylation and a substantial increase of glycolysis. The production of lactic acids, formed by pyruvate reduction, is also increased. Moreover, this pyruvate reduction prevents the start of the S-phase of the mitosis and its steady decrease in the cytoplasm (for the conversion into lactic acid) takes this block on mitosis away, pushing the cell towards uncontrolled proliferation.
So we have a modification of the intracellular pH that tends to become lightly alkaline, and a modification of the cellular respiration with a significant alteration of the Krebs cycle.
These facts together tend to result in an alteration in form and action of proteins and cytoplasmic enzymes, leading to a polymerization of RNA and a transfer of incorrect information between the ‘periphery’ and the ‘operative center’ (DNA). This leads to the mutation of the nuclear DNA and carcinogenesis.
In conclusion, the following hypothesis on which we are working now is that degeneration does not arise from a direct damage in the nuclear DNA, but from a problem in the cytoplasm, which means the damage occurs at the peripherical level (cell membrane). This would actually mean that operation of DNA can be strongly influenced by various components of the same cellular environment as well as by cell-to-cell signals.
From experience and data of Dr. Pantellini first and those of the Foundation now it seems that potassium ascorbate, also and especially in its newest formula with ribose, interferes with this process in a major way; it protects the cell against oxidative stress and inhibits the uncontrolled proliferation mechanism.
These facts can be related to the transporting (‘carrier’) characteristics of ascorbic acid for potassium (and with the catalytic activity of ribose in the ‘new’ formula) as a result from its heterocyclic structure, together with its antioxidant action.
The compound’s action is related to the characteristics of potassium as ‘guiding’ cation and metabolic regulator at intracellular level and to the ‘carrier’ action of vitamin C, which in this specific case performs a similar function to that of the sodium/potassium pump.
The release of potassium inside a cancerous cell can provoke a corresponding runoff of sodium (hence glucose) in the intracellular environment. In this way we can obtain:
Furthermore, potassium ascorbate can effectively serve on the level of prevention, maintaining constant intracellular potassium levels. In fact, as previously explained, the imbalance of these intracellular levels with the ‘intrusion’ of sodium from extracellular areas would be responsible for (or at least highly involved in) the chain of events that could lead to transformation of a cell into a neoplastic cell. Preventive intake of potassium ascorbate therefore has the objective to protect the cell from the risk of degeneration.
In recent years, the formula has been enriched with ribose which performs a catalytic activity, increasing the speed of the process by which potassium is transferred into cells. For further information, please go to the corresponding section on this website.
Preventive intake of the compound by adults generally consists of taking one dose per day, preferably in the morning on empty stomach 15 minutes before breakfast (unless otherwise indicated based on the evaluation of blood test/parameters).
In the presence of an oncologic disease it is generally recommended to take 3 daily doses (in the morning on empty stomach, 15 minutes before breakfast; and 45 minutes before lunch and dinner).
It is always advisable to have an assessment made by a competent person in order to be able to suggest the most appropriate dose for each situation.
Dr. Guido Paoli
Scientific director
(responsible for scientific research at the Pantellini Foundation)
Source: Potassium Ascorbate || Information - Fondazione Valsè Pantellini
What do the experts think of this?
I would like to hear opinions!
Thanks.
Also:
Truth
Cancer is not a disease. Not in the sense that has been given to this word. Nobel Prize winner Rita Levi-Montalcini already said this more than 50 years ago in a letter she wrote to her sister.
A TRANSLATED PART OF THE TEXT FROM THE LETTER TO HER SISTER:
‘First of all, cancer cannot be defined as a disease. At least not in the sense that is generally given to the term ‘disease’, which is a pathological process (either fast or slow, reversible or irreversible) of an organism, and does not take into account the causes. (…) Cancer is the revolt of a cell (which generates millions of them while multiplying) towards rules that regulate the development and vitality of the organism.’
(Ref: Levi-Montalcini R., ‘Letter from St. Louis’, 10 March 1951, reported/quoted in ‘Cantico di una vita’, Raffaello Cortina Ed., Milan, 2000.)
At the Pantellini Foundation we agree with Rita Levi-Montalcini and her letter. While developing this concept from our point of view, we believe that cancer is a defect in cell communication through which DNA receives and consequently evaluates and processes information. This defect leads the DNA to create modifications in some basic sequences that constitute the rungs of the spiral staircase, i.e. its double helix structure.
This would of course mean that the DNA is capable of interacting with the cytoplasmic environment and herewith surpasses, or better, breaks with what is considered the ‘central dogma of molecular biology’ that was introduced more than 30 years ago by Nobel Prize winner Francis Crick. According to his research, DNA works essentially one-way towards the synthesis of proteins and cannot receive any kind of instruction or information. We are deeply convinced however that in reality things are very different (see: Paoli G., La via del sale, Scienza e Conoscenza n. 21 (The way of salt, Science and Knowledge, n. 21), July 2007, reported at this website under the section ‘Learn more – Publications’).
In order to understand what cancer really is, we will probably have to reconsider and re-examine the evolution of life on our planet in depth, because we believe that somehow it has always been part of us. It is such a vast and complex matter that this page on our website is surely not enough to clarify the subject in the way we would like. We will probably be able to issue another publication soon that justifies our reflections on this matter.
This is obviously one of our interpretations that we would like to present being open to discussion and constructive criticism. We do not claim in any way, shape or form to hold the truth, simply because up to now no one holds the truth; everyone can contribute with his or her research, but should always be aware of the fact that what he or she believes to be the truth, could always be superseded by new data, new measures and new interpretations. As Mark Twain already said:
‘The trouble with the world is not that people know too little; it’s that they know so many things that just aren’t so’.
Source: Truth || - Fondazione Valsè Pantellini
And a link with all or alot scientific studies and sources: Studies || Publications - Fondazione Valsè Pantellini
POTASSIUM WITH RIBOSE
Potassium ascorbate with ribose is a salt derived from vitamin C that is completely non-toxic and free from side effects. The compound can be extemporaneously (i.e. without preparation) obtained by dissolving ascorbic acid (150 mg), potassium bicarbonate (300 mg, of which 117 mg potassium) and ribose (3 mg) in water. It has a pH level that tends to neutralize in less than a minute. The components have to be dissolved in 20 cc water (about two fingers high) without using a metallic spoon (because of the potential risk of oxidation of the ascorbic acid).
Oxidative processes linked to the presence of free radicals are involved in the impetus and development of cancer. Free radicals (substances with a high chemical reactivity) are the main reason for the mechanism of oxidative stress. Living organisms tend to maintain a constant level of the concentration of these oxidizing agents to ensure normal biological processes.
Based on the studies of dr. Pantellini, we are convinced that oxidative stress damages cell membrane structures, in particular the sodium/potassium ATP-ase (also known as the Na/K pump). This causes (an initially mild) depolarization and an increasingly greater alteration of the active transport mechanism of these two electrolytes. that have very different but fundamental functions in the cellular organization; potassium is the main regulator of intracellular metabolic processes through reversible salification of amino groups and imino of enzymes and proteins in a slightly acid environment; the other, sodium, is the main regulator of the alkaline reserve of the organism at extracellular level, with reversible salification of carboxylic groups of enzymes and proteins in a more or less basic environment.
In this way we obtain an increasingly bigger modification of the acid-based environment and redox-reactions between cytoplasmic molecules.
We are convinced that this fact constitutes the activating mechanism (trigger) for mutation into a cancerogene cell. In fact, research relating to the sarcoma (malignant tumor) of Rous that was already published in the 30′s (Moraveck e Kishi) proved that the neoplastic cell is lacking potassium and is rich of sodium, with an increasingly greater imbalance along with the development of cell degeneration.
This seems to be the common denominator in all neoplastic diseases and is also verifiable through a careful evaluation of the 4 hematic electrolytes (sodium, calcium, potassium, magnesium).
The described mechanism turns out to be very dangerous for the cell when:
These processes lead to a modification in cell respiration, with a decrease of oxiditative phosphorylation and a substantial increase of glycolysis. The production of lactic acids, formed by pyruvate reduction, is also increased. Furthermore this pyruvate reduction prevents the start of the S-phase of the mitosis and its steady decrease in the cytoplasm (for the conversion into lactic acid) takes this block on mitosis away, pushing the cell towards uncontrolled proliferation.
So we have a modification of the intracellular pH that tends to become lightly alkaline, and a modification of the cellular respiration with a significant alteration of the Krebs cycle.
These facts together tend to result in an alteration in form and action of proteins and cytoplasmic enzymes, leading to a polymerization of RNA and a transfer of incorrect information between the ‘periphery’ and the ‘operative center’ (DNA). This leads to the mutation of the nuclear DNA and carcinogenesis.
In conclusion, the following hypothesis on which we are working now is that degeneration does not arise from a direct damage in the nuclear DNA, but from a problem in the cytoplasm, which means the damage would occur at the peripherical level (cell membrane). This would actually mean that operation of DNA can be strongly influenced by various components of the same cellular environment as well as by cell-to-cell signals.
From experience and data of Dr. Pantellini first and those of the Foundation now it seems that potassium ascorbate with ribose interferes with this process in a major way; it protects the cell against oxidative stress and inhibits the uncontrolled proliferation mechanism.
The compound’s action is connected to the characteristics of potassium as ‘guiding’ cation and metabolic regulator at intracellular level and to the transporting (‘carrier’) action of vitamin C, which in this specific case performs a similar function to that of the sodium/potassium pump as a consequence of its heterocyclic structure.
The release of potassium inside a cancerous cell can provoke a corresponding runoff of sodium (hence glucose) in the intracellular environment. In this way we can obtain:
Ribose plays a very important role in cell metabolism. It is a sugar that is directly involved in the synthesis of nucleotides. It is a fundamental forerunner in the biosynthesis of RNA and adenosine, which is an essential component in the ATP and ATP-ase sodium-potassium production (the so-called Na/K pump) and in its deoxyribose form in the synthesis of DNA.
Our body is able to produce ribose. In certain conditions, however, this process of synthesis can be limited, or worse, damaged. This fact has already been pointed out in scientific research published in the United States in the ’50s.
When taken orally, ribose is metabolized and does not interfere (at least when taking the by the Pantellini Foundation recommended doses) with glycolysis.
Using a low concentration of ribose in respect to the quantity of ascorbid acid results in its potential catalytic activity; it accelerates the process of potassium absorption in the cytoplasmic cell, also because it does not follow the vitamin C process, which is transformed into oxalic acid and will leave the body via the kidneys just a few hours after intake, and it is ‘consumed’ in a different way.
Furthermore, potassium ascorbate can effectively serve at the level of prevention, maintaining constant intracellular potassium levels.
Preventive intake of potassium ascorbate therefore has the objective to ‘protect’ the cell from the risk of degeneration.
Preventive ingestion of the compound by adults generally consists of taking one dose per day, preferably in the morning on empty stomach 15 minutes before breakfast (unless otherwise indicated based on the evaluation of blood test/parameters).
In the presence of an oncologic disease it is generally recommended to take 3 daily doses (the morning on empty stomach, 15 minutes before breakfast; and 45 minutes before lunch and dinner).
It is always advisable to have an assessment made by a competent person in order to be able to suggest the most appropriate dose for each situation.
Dr. Guido Paoli
Scientific director
(responsible for scientific research at the Pantellini Foundation)
Source: Potassium with ribose || Information - Fondazione Valsè Pantellini
Also interesting:
"After the disastrous accident at the Chernobyl nuclear power plant in 1986, he offered his help to the people of the ex-Soviet Union that were directly affected by nuclear radiation, creating appropriate outlines (schemes) based on Potassium ascorbate intake. In honor of these efforts, he was awarded a Red Star Medal by the Russian Academy of Sciences in Moscow. The award certificate of honors mentions ‘outstanding achievements in science aimed at the population of de Soviet Union’ (this was in fact in 1987-1988, the period in which Gorbachev was the President of the USSR)."
Source: Gianfrancesco Valsè Pantellini || Informazioni - Fondazione Valsè Pantellini
Full text:
GIANFRANCESCO VALSÈ PANTELLINI
This is a story about a discovery that occurred by chance, as often happens in physics and science. Science is not only about the great events. It is about being able to be wondered by the small things, that makes a person great.
Dr. Gianfrancesco Valsè Pantellini was born on April 2, 1917 in Ruffina, a small village in Tuscany, where he lived together with his father Italo and his mother Margherita until 1929. Paternal influence (his father was a doctor) and the boy’s curiosity led him on the path of scientific research and he began to devote himself to electrochemical studies together with the pharmacist of the village.
He continues his studies in Florence, first at the La Querce College and later at the private high school Liceo Michelangelo where he obtained his diploma studying 3 years in just 1 academic year. He enrolled at the University of Florence, Faculty of Chemistry in 1936 and took the specialization Bio-organic Chemistry.
Although the war interrupted his studies, he remained active in this field serving as Chemical Official (officer in chemical engineering) at the Genio Guastatori, a department of the Italian army, and worked at various locations such as Udine (north of Italy), Russia and France. In 1943, he meets the famous mathematician Luigi Fantappiè in Rome.
After the war, he resumes his studies in Florence where he graduated in Bio-organic Chemistry in 1947. He then attends the Institute of Theoretical Physics in Naples for a year. During a stay in Paris, he meets physician Louis Kervran and deepens his research on cold fusion in the human body.
After coming back to Florence again, he decides to go to the Autonomous Tumor Center in Ancona (Centro Autonomo Tumori) where he collaborated for more than a year with professors Protti, Gusso and Neubauer. He had his first experiences here following enzymatic research of yeast and their pyroertic action towards the neoplastic cell.
He returned to Florence in 1949 and while he worked for several small pharmaceutical companies, in private he was dedicated to researching tumors. He personally participated in different congresses on Cancerology including those in Florence, Cremona, Baden Baden and New York. Being part of an international research group on cancer that used non-conventional research methods, he was nominated Member of the prestigious New York Academy of Sciences (NYAS) and the International Society for Cryosurgery.
After the disastrous accident at the Chernobyl nuclear power plant in 1986, he offered his help to the people of the ex-Soviet Union that were directly affected by nuclear radiation, creating appropriate outlines (schemes) based on Potassium ascorbate intake. In honor of these efforts, he was awarded a Red Star Medal by the Russian Academy of Sciences in Moscow. The award certificate of honors mentions ‘outstanding achievements in science aimed at the population of de Soviet Union’ (this was in fact in 1987-1988, the period in which Gorbachev was the President of the USSR).
The discovery really happened by accident in 1947. A Florentine goldsmith named Giovanni that Valsè Pantellini was well acquainted with fell ill with stomach cancer. Prof. Valdoni diagnosed him inoperable, indicating he would just have a few months left to live. Suffering from severe stomach pain, Valsè Pantellini advised the goldsmith to take lemon juice with bicarbonate.
Deeply concerned about the health condition of Giovanni, Pantellini goes to visit the man after one year and finds him completely recovered, fit as a fiddle even. Somewhat surprised he asked him what kind of cure he had been taking. Giovanni answered that he simply continued taking lemon juice with bicarbonate as suggested by Pantellini. He then took a closer look at the jar from which Giovanni had been adding with a teaspoon a small amount of bicarbonate into the lemon juice and saw that the jar had an unusual appearance. He turned it around to read the label and noticed that instead of sodium bicarbonate, he had been taking potassium bicarbonate!
The man lived another twenty years and then died because of a heart attack.
‘It was mind-blowing to see this unexpected miracle, which was actually the result of a misunderstanding’, describes Pantellini one day. ‘I made the radiologists double-check because I thought they made a mistake with the X-rays, but no, the results were real. This fact made me think a lot and I began to wonder what had happened’.
He then retrieved the results of an old research done by Moraweck and Kishi in 1932, in which they emphasized a high percentage of potassium inside healthy cells, and a low percentage of potassium in neoplastic tissue and non-neoplastic tissue that carried a malignant tumor. At that moment, Pantellini’s potassium ascorbate ‘adventure’ started.
We have to underline that the first scientific work of Dr. Pantellini was presented and published in the Journal of Medical Pathology not earlier than 1970, more than 22 years after this important encounter. Dr. Pantellini was part of an (unfortunately increasingly rare) array of people that feels the necessity to verify, experiment, prove again and analyze something in depth before talking about it in public. Only when he was reasonably sure of the credibility and reproducibility of his data, he decided to officially present the fruits of his labor.
This work was followed by another study published 4 years later (1974) in the same Journal and then, apart from Andromeda’s ‘last’ publication ‘The co-factor K+, 50 years of research and therapy against tumors’, further publications ceased. To requests for new publications Pantellini’s answer was always the same: ‘I said what I had to say. Now it is up to others to verify it. I cannot lose time writing, I have to work!’, meaning that he would continuously have to answer people addressing him while he just wanted to continue his research and study in order to discover new pathways and insights on the matter.
This is when he came to the intuitive idea of introducing ribose into the compound.
With this website, we would like to honor the moral and professional stature of this extraordinary man and his great contribution to humanity. He was humble and dignified, always respectful towards people and patients in particular.
In order that Pantellini’s work and insights become more and more noted, the Pantellini Foundation will unworthily and undeservingly continue his work, so that more and more people can experiment and verify that what we present is not just nonsense or worse, speculation, but instead represents an important resource for all of us.
An excerpt on D-Ribose:
CAUTION: Do not take D-ribose if you are younger than 60, and then only if monitored by a medical practitioner knowing expected length of life, and assessment of risk/benefit which includes analysis of overall lifetime dietary sugars, animal proteins and fats, and family history for cancers and dementia. These might indicate damage already present from AGEs. Wow, now that is a real bombshell.
Why? Research out of China reveals that D-ribose participates in forming AGEs faster than any other form of sugar. AGEs are indicated in many degenerative diseases, including Alzheimer's. ref Plus, cancer cells use more ribose than normal cells to grow faster. Thus, the under 60 should especially use with caution. Every little bit builds up and at some point, it may be too late to correct or mitigate these influences. ref
EVERYTHING IS ALWAYS A MATTER OF DEGREES. IF OVERALL SUGAR IN DIET IS LOW, RIBOSE USE WOULD HAVE LESS OF AN EFFECT. But, the typical American diet is fat too high in sugars and oxidizing stress that adding D-Ribose could push glycation activities into overdrive. If cancer not present, Ribose could help prevent, but if there is a family history, best to stay away.
Testing safety of Ribose might not have lasted long enough for AGEs to be detected, or even associated. Yes, most references used animal studies and more research in humans is vitally needed. Benefits have to be balanced against risks, and using age as a factor for how long it takes AGEs to form and Ribose to influence health. Or at what amount Ribose would impact AGEs formation compared to overall sugar amounts in diet. Short term use may be more appropriate. Here is the research for the DO NOT USE recommendation for RIBOSE. ref ref ref
One nutrient of value to help slow down or prevent AGEs formation, Carnosine. ref
Here is a study looking at the amount of AGEs already formed in different foods, often influenced by cooking methods and temperatures, and their effects on inflammatory markers after consumption by diabetics. ref Look at the changes on some of these inflammation markers. This is a very revealing important small study on the impact of diet and cooking methods on health. Foods with high AGEs already formed, increase the amount of AGEs the body produces.
Ribose and Cancer
It is of interest to note that ribose can play a positive role with potassium in cancer cells. At just the right concentration, ribose may carry potassium into cancer cells which slows the division rate of these cells. D-ribose also participates in Krebs pathway to supply energy to healthy cells, but cancer cells must hinder this uptake by healthy cells and take more for themselves. More to discover here.
Source: D-Ribose - Supplements of Merit - Vitaminworkshop.com
So D-Ribose is something one should be cautious about. I wonder what Ray Peat's comment on potassium ascorbate and D-Ribose would be.
Further links definitely worth the read:
How to use || - Fondazione Valsè Pantellini
Prevention || - Fondazione Valsè Pantellini
FAQ || - Fondazione Valsè Pantellini
From the FAQ:
2) Why is potassium ascorbate not officially recognized (yet)?
Experts in the medical-scientific field often do not know the grounds and foundations of the Pantellini method. Some publications date back more than 40 years and only a few recent publications have been made, almost all exclusively by the Pantellini Foundation, as much as to this point where people often tend to confuse potassium ascorbate, with or without ribose, with ‘simple’ vitamin C. It is even often said that taking an orange juice or a banana will do! In reality, as we have already repeated multiple times on this site, potassium ascorbate is a salt derived from vitamin C and works completely differently.
Moreover, speaking of ‘simple’ vitamin C brings to mind Pauling, Cameron and Wilson’s work in the 60s-70s, who obtained apparently contradictory results using very high doses (a couple dozens of grams) of ascorbic acid distributed intravenously. In this case, it has to be noted however that in reality this procedure leads to a formation of a derivative salt known as sodium ascorbate, and not to potassium ascorbate!
Unfortunately there is an observed tendency to place the method based on potassium ascorbate (with or without ribose) in the field of the so-called ‘alternative therapies’ (see previous question), which basically induces a defensive attitude and a pronounced exclusion (ostracism) from the part of health care facilities.
On the other hand, many doctors and researchers, not only in Italy but also from other parts of Europe and the world, are aware of the studies of Dr. Pantellini and have been able to experience the potential beneficial effects directly on their own patients. Unfortunately, due to the current prevailing professional ostracizable atmosphere and bureaucratic difficulties, the argument often (but fortunately not always!) gets put down. In the best case, it is conveyed through direct informal contact between people based on the word of mouth.
There is also the widespread, but in our view decisively unscientific belief that such a complex problem like cell degeneration requires a similar complex and thus costly solution. The research on particular controlling enzymes for example, or the activation and deactivation of appropriate genes, or the formation of new, highly selected medication, are methodologies that require enormous expenditure and highly specialized laboratories.
Since all over the world unimaginable amounts of money (tens of millions of euros!) are being invested in trying to find solutions that are still, unfortunately, far from being found, people consequently tend to exclude that with potassium bicarbonate and a bit of lemon juice significant benefits and results can be obtained.
Moreover, excessive specialization and concentrating too much on particular questions and issues can lead to losing sight of the ‘general vision’ of a problem. It is like looking at a forest from too close and thus only seeing the bark of a single tree. This could limit our capacity to identify other paths to follow.
Another aspect that cannot be neglected is that the potassium ascorbate method (with or without ribose) has extremely limited costs compared to any other drug or medication in use and it almost seems that it might therefore not be interesting enough from the pharmaceutical point of view.
FAQ || - Fondazione Valsè Pantellini
The compound can be extemporaneously (i.e. without any preparation) obtained by dissolving ascorbic acid (150 mg) and potassium bicarbonate (300 mg of which 117 mg potassium) in water. It has a pH level that tends to neutralize in less than a minute. The two components have to be dissolved in 20 cc water (about two fingers high) without using a metallic spoon (because of the potential risk of oxidation of the ascorbic acid).
Potassium ascorbate is related to the studies and research of the Florentine biochemist Dr. Gianfrancesco Valsè Pantellini and its ‘story’ starts in 1948 when a goldsmith and friend of Dr. Pantellini, affected with inoperable stomach cancer, experiences unexpectedly and absolutely extraordinary results after taking lemon juice in which he accidentally dissolved potassium bicarbonate instead of sodium bicarbonate. Pantellini studied and analyzed this subject for about twenty years, leading to two specific publications in 1970 and 1974 in the Journal of Medical Pathology.
Oxidative processes linked to the presence of free radicals are involved in the impetus and development of cancer. Free radicals (substances with a high chemical reactivity) are the main reason for the mechanism of oxidative stress. Living organisms tend to maintain a constant level of the concentration of these oxidizing agents to ensure normal biological processes.
Based on the studies of Dr. Pantellini, we are convinced that oxidative stress damages cell membrane structures, in particular the sodium-potassium ATPase (also known as the Na/K pump). This causes (an initially mild) depolarization and an increasingly greater alteration of the active transport mechanism of these two electrolytes, that have very different but fundamental functions in the cellular organization; potassium is the main regulator of intracellular metabolic processes through reversible salification of amino groups and imino of enzymes and proteins in a slightly acid environment; the other, sodium, is the main regulator of the alkaline reserve of the organism at extracellular level, with reversible salification of carboxylic groups of enzymes and proteins in a more or less basic environment.
In this way we obtain an increasingly bigger modification of the acid-based environment and redox-reactions between cytoplasmic molecules.
We are convinced that this fact constitutes the activating mechanism (trigger) for mutation into a cancerogene cell. In fact, research relating to the sarcoma (malignant tumor) of Rous that was already published in the 30′s (Moraveck and Kishi) proved that the neoplastic cell is lacking potassium and rich of sodium, with an increasingly greater imbalance along with the development of cell degeneration.
This seems to be the common denominator in all neoplastic diseases and is also verifiable through a careful evaluation of the four hematic electrolytes (sodium, calcium, potassium, magnesium) in the blood.
The described mechanism turns out to be very dangerous for the cell when:
- it activates a rapid transfer of calcium from intracellular deposits (mitochondria), that could be responsible for mitogenic activation (i.e. cell duplication);
- it allows a considerable transport of glucose into the cytoplasm (together with sodium, SGLUT symport) with a speed that increases along with the increasingly greater alteration of the sodium/potassium pump (which is the only active control element of the two electrolytes).
These processes lead to a modification in cell respiration, with a decrease of oxidative phosphorylation and a substantial increase of glycolysis. The production of lactic acids, formed by pyruvate reduction, is also increased. Moreover, this pyruvate reduction prevents the start of the S-phase of the mitosis and its steady decrease in the cytoplasm (for the conversion into lactic acid) takes this block on mitosis away, pushing the cell towards uncontrolled proliferation.
So we have a modification of the intracellular pH that tends to become lightly alkaline, and a modification of the cellular respiration with a significant alteration of the Krebs cycle.
These facts together tend to result in an alteration in form and action of proteins and cytoplasmic enzymes, leading to a polymerization of RNA and a transfer of incorrect information between the ‘periphery’ and the ‘operative center’ (DNA). This leads to the mutation of the nuclear DNA and carcinogenesis.
In conclusion, the following hypothesis on which we are working now is that degeneration does not arise from a direct damage in the nuclear DNA, but from a problem in the cytoplasm, which means the damage occurs at the peripherical level (cell membrane). This would actually mean that operation of DNA can be strongly influenced by various components of the same cellular environment as well as by cell-to-cell signals.
From experience and data of Dr. Pantellini first and those of the Foundation now it seems that potassium ascorbate, also and especially in its newest formula with ribose, interferes with this process in a major way; it protects the cell against oxidative stress and inhibits the uncontrolled proliferation mechanism.
These facts can be related to the transporting (‘carrier’) characteristics of ascorbic acid for potassium (and with the catalytic activity of ribose in the ‘new’ formula) as a result from its heterocyclic structure, together with its antioxidant action.
The compound’s action is related to the characteristics of potassium as ‘guiding’ cation and metabolic regulator at intracellular level and to the ‘carrier’ action of vitamin C, which in this specific case performs a similar function to that of the sodium/potassium pump.
The release of potassium inside a cancerous cell can provoke a corresponding runoff of sodium (hence glucose) in the intracellular environment. In this way we can obtain:
- a new modification of the local, intracellular pH;
- a rapid decrease of nutritional reserves reducing glycolysis and re-establishing the potential block on mitosis. Thus, it seems possible to inhibit the uncontrolled proliferation process.
Furthermore, potassium ascorbate can effectively serve on the level of prevention, maintaining constant intracellular potassium levels. In fact, as previously explained, the imbalance of these intracellular levels with the ‘intrusion’ of sodium from extracellular areas would be responsible for (or at least highly involved in) the chain of events that could lead to transformation of a cell into a neoplastic cell. Preventive intake of potassium ascorbate therefore has the objective to protect the cell from the risk of degeneration.
In recent years, the formula has been enriched with ribose which performs a catalytic activity, increasing the speed of the process by which potassium is transferred into cells. For further information, please go to the corresponding section on this website.
Preventive intake of the compound by adults generally consists of taking one dose per day, preferably in the morning on empty stomach 15 minutes before breakfast (unless otherwise indicated based on the evaluation of blood test/parameters).
In the presence of an oncologic disease it is generally recommended to take 3 daily doses (in the morning on empty stomach, 15 minutes before breakfast; and 45 minutes before lunch and dinner).
It is always advisable to have an assessment made by a competent person in order to be able to suggest the most appropriate dose for each situation.
Dr. Guido Paoli
Scientific director
(responsible for scientific research at the Pantellini Foundation)
Source: Potassium Ascorbate || Information - Fondazione Valsè Pantellini
What do the experts think of this?
I would like to hear opinions!
Thanks.
Also:
Truth
Cancer is not a disease. Not in the sense that has been given to this word. Nobel Prize winner Rita Levi-Montalcini already said this more than 50 years ago in a letter she wrote to her sister.
A TRANSLATED PART OF THE TEXT FROM THE LETTER TO HER SISTER:
‘First of all, cancer cannot be defined as a disease. At least not in the sense that is generally given to the term ‘disease’, which is a pathological process (either fast or slow, reversible or irreversible) of an organism, and does not take into account the causes. (…) Cancer is the revolt of a cell (which generates millions of them while multiplying) towards rules that regulate the development and vitality of the organism.’
(Ref: Levi-Montalcini R., ‘Letter from St. Louis’, 10 March 1951, reported/quoted in ‘Cantico di una vita’, Raffaello Cortina Ed., Milan, 2000.)
At the Pantellini Foundation we agree with Rita Levi-Montalcini and her letter. While developing this concept from our point of view, we believe that cancer is a defect in cell communication through which DNA receives and consequently evaluates and processes information. This defect leads the DNA to create modifications in some basic sequences that constitute the rungs of the spiral staircase, i.e. its double helix structure.
This would of course mean that the DNA is capable of interacting with the cytoplasmic environment and herewith surpasses, or better, breaks with what is considered the ‘central dogma of molecular biology’ that was introduced more than 30 years ago by Nobel Prize winner Francis Crick. According to his research, DNA works essentially one-way towards the synthesis of proteins and cannot receive any kind of instruction or information. We are deeply convinced however that in reality things are very different (see: Paoli G., La via del sale, Scienza e Conoscenza n. 21 (The way of salt, Science and Knowledge, n. 21), July 2007, reported at this website under the section ‘Learn more – Publications’).
In order to understand what cancer really is, we will probably have to reconsider and re-examine the evolution of life on our planet in depth, because we believe that somehow it has always been part of us. It is such a vast and complex matter that this page on our website is surely not enough to clarify the subject in the way we would like. We will probably be able to issue another publication soon that justifies our reflections on this matter.
This is obviously one of our interpretations that we would like to present being open to discussion and constructive criticism. We do not claim in any way, shape or form to hold the truth, simply because up to now no one holds the truth; everyone can contribute with his or her research, but should always be aware of the fact that what he or she believes to be the truth, could always be superseded by new data, new measures and new interpretations. As Mark Twain already said:
‘The trouble with the world is not that people know too little; it’s that they know so many things that just aren’t so’.
Source: Truth || - Fondazione Valsè Pantellini
And a link with all or alot scientific studies and sources: Studies || Publications - Fondazione Valsè Pantellini
POTASSIUM WITH RIBOSE
Potassium ascorbate with ribose is a salt derived from vitamin C that is completely non-toxic and free from side effects. The compound can be extemporaneously (i.e. without preparation) obtained by dissolving ascorbic acid (150 mg), potassium bicarbonate (300 mg, of which 117 mg potassium) and ribose (3 mg) in water. It has a pH level that tends to neutralize in less than a minute. The components have to be dissolved in 20 cc water (about two fingers high) without using a metallic spoon (because of the potential risk of oxidation of the ascorbic acid).
Oxidative processes linked to the presence of free radicals are involved in the impetus and development of cancer. Free radicals (substances with a high chemical reactivity) are the main reason for the mechanism of oxidative stress. Living organisms tend to maintain a constant level of the concentration of these oxidizing agents to ensure normal biological processes.
Based on the studies of dr. Pantellini, we are convinced that oxidative stress damages cell membrane structures, in particular the sodium/potassium ATP-ase (also known as the Na/K pump). This causes (an initially mild) depolarization and an increasingly greater alteration of the active transport mechanism of these two electrolytes. that have very different but fundamental functions in the cellular organization; potassium is the main regulator of intracellular metabolic processes through reversible salification of amino groups and imino of enzymes and proteins in a slightly acid environment; the other, sodium, is the main regulator of the alkaline reserve of the organism at extracellular level, with reversible salification of carboxylic groups of enzymes and proteins in a more or less basic environment.
In this way we obtain an increasingly bigger modification of the acid-based environment and redox-reactions between cytoplasmic molecules.
We are convinced that this fact constitutes the activating mechanism (trigger) for mutation into a cancerogene cell. In fact, research relating to the sarcoma (malignant tumor) of Rous that was already published in the 30′s (Moraveck e Kishi) proved that the neoplastic cell is lacking potassium and is rich of sodium, with an increasingly greater imbalance along with the development of cell degeneration.
This seems to be the common denominator in all neoplastic diseases and is also verifiable through a careful evaluation of the 4 hematic electrolytes (sodium, calcium, potassium, magnesium).
The described mechanism turns out to be very dangerous for the cell when:
- it activates a rapid transfer of calcium from intracellular deposits (mitochondria), that could be responsible for mitogenic activation (i.e. cell duplication);
- it allows a considerable transport of glucose in the cytoplasm (together with sodium, SGLUT symport), with a speed that increases along with the increasingly greater alteration of the sodium/potassium pump (which is the only active control element on the two electrolytes).
These processes lead to a modification in cell respiration, with a decrease of oxiditative phosphorylation and a substantial increase of glycolysis. The production of lactic acids, formed by pyruvate reduction, is also increased. Furthermore this pyruvate reduction prevents the start of the S-phase of the mitosis and its steady decrease in the cytoplasm (for the conversion into lactic acid) takes this block on mitosis away, pushing the cell towards uncontrolled proliferation.
So we have a modification of the intracellular pH that tends to become lightly alkaline, and a modification of the cellular respiration with a significant alteration of the Krebs cycle.
These facts together tend to result in an alteration in form and action of proteins and cytoplasmic enzymes, leading to a polymerization of RNA and a transfer of incorrect information between the ‘periphery’ and the ‘operative center’ (DNA). This leads to the mutation of the nuclear DNA and carcinogenesis.
In conclusion, the following hypothesis on which we are working now is that degeneration does not arise from a direct damage in the nuclear DNA, but from a problem in the cytoplasm, which means the damage would occur at the peripherical level (cell membrane). This would actually mean that operation of DNA can be strongly influenced by various components of the same cellular environment as well as by cell-to-cell signals.
From experience and data of Dr. Pantellini first and those of the Foundation now it seems that potassium ascorbate with ribose interferes with this process in a major way; it protects the cell against oxidative stress and inhibits the uncontrolled proliferation mechanism.
The compound’s action is connected to the characteristics of potassium as ‘guiding’ cation and metabolic regulator at intracellular level and to the transporting (‘carrier’) action of vitamin C, which in this specific case performs a similar function to that of the sodium/potassium pump as a consequence of its heterocyclic structure.
The release of potassium inside a cancerous cell can provoke a corresponding runoff of sodium (hence glucose) in the intracellular environment. In this way we can obtain:
- a new modification of the local, intracellular pH
- a rapid decrease of nutritional reserves, reducing glycolysis and re-establishing the potential block on mitosis. Thus, it seems possible to inhibit the uncontrolled proliferation process.
Ribose plays a very important role in cell metabolism. It is a sugar that is directly involved in the synthesis of nucleotides. It is a fundamental forerunner in the biosynthesis of RNA and adenosine, which is an essential component in the ATP and ATP-ase sodium-potassium production (the so-called Na/K pump) and in its deoxyribose form in the synthesis of DNA.
Our body is able to produce ribose. In certain conditions, however, this process of synthesis can be limited, or worse, damaged. This fact has already been pointed out in scientific research published in the United States in the ’50s.
When taken orally, ribose is metabolized and does not interfere (at least when taking the by the Pantellini Foundation recommended doses) with glycolysis.
Using a low concentration of ribose in respect to the quantity of ascorbid acid results in its potential catalytic activity; it accelerates the process of potassium absorption in the cytoplasmic cell, also because it does not follow the vitamin C process, which is transformed into oxalic acid and will leave the body via the kidneys just a few hours after intake, and it is ‘consumed’ in a different way.
Furthermore, potassium ascorbate can effectively serve at the level of prevention, maintaining constant intracellular potassium levels.
Preventive intake of potassium ascorbate therefore has the objective to ‘protect’ the cell from the risk of degeneration.
Preventive ingestion of the compound by adults generally consists of taking one dose per day, preferably in the morning on empty stomach 15 minutes before breakfast (unless otherwise indicated based on the evaluation of blood test/parameters).
In the presence of an oncologic disease it is generally recommended to take 3 daily doses (the morning on empty stomach, 15 minutes before breakfast; and 45 minutes before lunch and dinner).
It is always advisable to have an assessment made by a competent person in order to be able to suggest the most appropriate dose for each situation.
Dr. Guido Paoli
Scientific director
(responsible for scientific research at the Pantellini Foundation)
Source: Potassium with ribose || Information - Fondazione Valsè Pantellini
Also interesting:
"After the disastrous accident at the Chernobyl nuclear power plant in 1986, he offered his help to the people of the ex-Soviet Union that were directly affected by nuclear radiation, creating appropriate outlines (schemes) based on Potassium ascorbate intake. In honor of these efforts, he was awarded a Red Star Medal by the Russian Academy of Sciences in Moscow. The award certificate of honors mentions ‘outstanding achievements in science aimed at the population of de Soviet Union’ (this was in fact in 1987-1988, the period in which Gorbachev was the President of the USSR)."
Source: Gianfrancesco Valsè Pantellini || Informazioni - Fondazione Valsè Pantellini
Full text:
GIANFRANCESCO VALSÈ PANTELLINI
This is a story about a discovery that occurred by chance, as often happens in physics and science. Science is not only about the great events. It is about being able to be wondered by the small things, that makes a person great.
Dr. Gianfrancesco Valsè Pantellini was born on April 2, 1917 in Ruffina, a small village in Tuscany, where he lived together with his father Italo and his mother Margherita until 1929. Paternal influence (his father was a doctor) and the boy’s curiosity led him on the path of scientific research and he began to devote himself to electrochemical studies together with the pharmacist of the village.
He continues his studies in Florence, first at the La Querce College and later at the private high school Liceo Michelangelo where he obtained his diploma studying 3 years in just 1 academic year. He enrolled at the University of Florence, Faculty of Chemistry in 1936 and took the specialization Bio-organic Chemistry.
Although the war interrupted his studies, he remained active in this field serving as Chemical Official (officer in chemical engineering) at the Genio Guastatori, a department of the Italian army, and worked at various locations such as Udine (north of Italy), Russia and France. In 1943, he meets the famous mathematician Luigi Fantappiè in Rome.
After the war, he resumes his studies in Florence where he graduated in Bio-organic Chemistry in 1947. He then attends the Institute of Theoretical Physics in Naples for a year. During a stay in Paris, he meets physician Louis Kervran and deepens his research on cold fusion in the human body.
After coming back to Florence again, he decides to go to the Autonomous Tumor Center in Ancona (Centro Autonomo Tumori) where he collaborated for more than a year with professors Protti, Gusso and Neubauer. He had his first experiences here following enzymatic research of yeast and their pyroertic action towards the neoplastic cell.
He returned to Florence in 1949 and while he worked for several small pharmaceutical companies, in private he was dedicated to researching tumors. He personally participated in different congresses on Cancerology including those in Florence, Cremona, Baden Baden and New York. Being part of an international research group on cancer that used non-conventional research methods, he was nominated Member of the prestigious New York Academy of Sciences (NYAS) and the International Society for Cryosurgery.
After the disastrous accident at the Chernobyl nuclear power plant in 1986, he offered his help to the people of the ex-Soviet Union that were directly affected by nuclear radiation, creating appropriate outlines (schemes) based on Potassium ascorbate intake. In honor of these efforts, he was awarded a Red Star Medal by the Russian Academy of Sciences in Moscow. The award certificate of honors mentions ‘outstanding achievements in science aimed at the population of de Soviet Union’ (this was in fact in 1987-1988, the period in which Gorbachev was the President of the USSR).
The discovery really happened by accident in 1947. A Florentine goldsmith named Giovanni that Valsè Pantellini was well acquainted with fell ill with stomach cancer. Prof. Valdoni diagnosed him inoperable, indicating he would just have a few months left to live. Suffering from severe stomach pain, Valsè Pantellini advised the goldsmith to take lemon juice with bicarbonate.
Deeply concerned about the health condition of Giovanni, Pantellini goes to visit the man after one year and finds him completely recovered, fit as a fiddle even. Somewhat surprised he asked him what kind of cure he had been taking. Giovanni answered that he simply continued taking lemon juice with bicarbonate as suggested by Pantellini. He then took a closer look at the jar from which Giovanni had been adding with a teaspoon a small amount of bicarbonate into the lemon juice and saw that the jar had an unusual appearance. He turned it around to read the label and noticed that instead of sodium bicarbonate, he had been taking potassium bicarbonate!
The man lived another twenty years and then died because of a heart attack.
‘It was mind-blowing to see this unexpected miracle, which was actually the result of a misunderstanding’, describes Pantellini one day. ‘I made the radiologists double-check because I thought they made a mistake with the X-rays, but no, the results were real. This fact made me think a lot and I began to wonder what had happened’.
He then retrieved the results of an old research done by Moraweck and Kishi in 1932, in which they emphasized a high percentage of potassium inside healthy cells, and a low percentage of potassium in neoplastic tissue and non-neoplastic tissue that carried a malignant tumor. At that moment, Pantellini’s potassium ascorbate ‘adventure’ started.
We have to underline that the first scientific work of Dr. Pantellini was presented and published in the Journal of Medical Pathology not earlier than 1970, more than 22 years after this important encounter. Dr. Pantellini was part of an (unfortunately increasingly rare) array of people that feels the necessity to verify, experiment, prove again and analyze something in depth before talking about it in public. Only when he was reasonably sure of the credibility and reproducibility of his data, he decided to officially present the fruits of his labor.
This work was followed by another study published 4 years later (1974) in the same Journal and then, apart from Andromeda’s ‘last’ publication ‘The co-factor K+, 50 years of research and therapy against tumors’, further publications ceased. To requests for new publications Pantellini’s answer was always the same: ‘I said what I had to say. Now it is up to others to verify it. I cannot lose time writing, I have to work!’, meaning that he would continuously have to answer people addressing him while he just wanted to continue his research and study in order to discover new pathways and insights on the matter.
This is when he came to the intuitive idea of introducing ribose into the compound.
With this website, we would like to honor the moral and professional stature of this extraordinary man and his great contribution to humanity. He was humble and dignified, always respectful towards people and patients in particular.
In order that Pantellini’s work and insights become more and more noted, the Pantellini Foundation will unworthily and undeservingly continue his work, so that more and more people can experiment and verify that what we present is not just nonsense or worse, speculation, but instead represents an important resource for all of us.
An excerpt on D-Ribose:
CAUTION: Do not take D-ribose if you are younger than 60, and then only if monitored by a medical practitioner knowing expected length of life, and assessment of risk/benefit which includes analysis of overall lifetime dietary sugars, animal proteins and fats, and family history for cancers and dementia. These might indicate damage already present from AGEs. Wow, now that is a real bombshell.
Why? Research out of China reveals that D-ribose participates in forming AGEs faster than any other form of sugar. AGEs are indicated in many degenerative diseases, including Alzheimer's. ref Plus, cancer cells use more ribose than normal cells to grow faster. Thus, the under 60 should especially use with caution. Every little bit builds up and at some point, it may be too late to correct or mitigate these influences. ref
EVERYTHING IS ALWAYS A MATTER OF DEGREES. IF OVERALL SUGAR IN DIET IS LOW, RIBOSE USE WOULD HAVE LESS OF AN EFFECT. But, the typical American diet is fat too high in sugars and oxidizing stress that adding D-Ribose could push glycation activities into overdrive. If cancer not present, Ribose could help prevent, but if there is a family history, best to stay away.
Testing safety of Ribose might not have lasted long enough for AGEs to be detected, or even associated. Yes, most references used animal studies and more research in humans is vitally needed. Benefits have to be balanced against risks, and using age as a factor for how long it takes AGEs to form and Ribose to influence health. Or at what amount Ribose would impact AGEs formation compared to overall sugar amounts in diet. Short term use may be more appropriate. Here is the research for the DO NOT USE recommendation for RIBOSE. ref ref ref
One nutrient of value to help slow down or prevent AGEs formation, Carnosine. ref
Here is a study looking at the amount of AGEs already formed in different foods, often influenced by cooking methods and temperatures, and their effects on inflammatory markers after consumption by diabetics. ref Look at the changes on some of these inflammation markers. This is a very revealing important small study on the impact of diet and cooking methods on health. Foods with high AGEs already formed, increase the amount of AGEs the body produces.
Ribose and Cancer
It is of interest to note that ribose can play a positive role with potassium in cancer cells. At just the right concentration, ribose may carry potassium into cancer cells which slows the division rate of these cells. D-ribose also participates in Krebs pathway to supply energy to healthy cells, but cancer cells must hinder this uptake by healthy cells and take more for themselves. More to discover here.
Source: D-Ribose - Supplements of Merit - Vitaminworkshop.com
So D-Ribose is something one should be cautious about. I wonder what Ray Peat's comment on potassium ascorbate and D-Ribose would be.
Further links definitely worth the read:
How to use || - Fondazione Valsè Pantellini
Prevention || - Fondazione Valsè Pantellini
FAQ || - Fondazione Valsè Pantellini
From the FAQ:
2) Why is potassium ascorbate not officially recognized (yet)?
Experts in the medical-scientific field often do not know the grounds and foundations of the Pantellini method. Some publications date back more than 40 years and only a few recent publications have been made, almost all exclusively by the Pantellini Foundation, as much as to this point where people often tend to confuse potassium ascorbate, with or without ribose, with ‘simple’ vitamin C. It is even often said that taking an orange juice or a banana will do! In reality, as we have already repeated multiple times on this site, potassium ascorbate is a salt derived from vitamin C and works completely differently.
Moreover, speaking of ‘simple’ vitamin C brings to mind Pauling, Cameron and Wilson’s work in the 60s-70s, who obtained apparently contradictory results using very high doses (a couple dozens of grams) of ascorbic acid distributed intravenously. In this case, it has to be noted however that in reality this procedure leads to a formation of a derivative salt known as sodium ascorbate, and not to potassium ascorbate!
Unfortunately there is an observed tendency to place the method based on potassium ascorbate (with or without ribose) in the field of the so-called ‘alternative therapies’ (see previous question), which basically induces a defensive attitude and a pronounced exclusion (ostracism) from the part of health care facilities.
On the other hand, many doctors and researchers, not only in Italy but also from other parts of Europe and the world, are aware of the studies of Dr. Pantellini and have been able to experience the potential beneficial effects directly on their own patients. Unfortunately, due to the current prevailing professional ostracizable atmosphere and bureaucratic difficulties, the argument often (but fortunately not always!) gets put down. In the best case, it is conveyed through direct informal contact between people based on the word of mouth.
There is also the widespread, but in our view decisively unscientific belief that such a complex problem like cell degeneration requires a similar complex and thus costly solution. The research on particular controlling enzymes for example, or the activation and deactivation of appropriate genes, or the formation of new, highly selected medication, are methodologies that require enormous expenditure and highly specialized laboratories.
Since all over the world unimaginable amounts of money (tens of millions of euros!) are being invested in trying to find solutions that are still, unfortunately, far from being found, people consequently tend to exclude that with potassium bicarbonate and a bit of lemon juice significant benefits and results can be obtained.
Moreover, excessive specialization and concentrating too much on particular questions and issues can lead to losing sight of the ‘general vision’ of a problem. It is like looking at a forest from too close and thus only seeing the bark of a single tree. This could limit our capacity to identify other paths to follow.
Another aspect that cannot be neglected is that the potassium ascorbate method (with or without ribose) has extremely limited costs compared to any other drug or medication in use and it almost seems that it might therefore not be interesting enough from the pharmaceutical point of view.
FAQ || - Fondazione Valsè Pantellini
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