ALS
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- Joined
- Sep 3, 2017
- Messages
- 206
I am already on Armour NDT 90 mg. Is there any good reason to add T2? Essential T2 | Bioidentical T2 Thyroid Hormone (3,5 Diiodo-L-Thyronine)
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Good summary:T2 as weight loss supplement is not new and I think this will answer most of your questions: 3,5-Diiodo-L-Thyronine (T2) in Dietary Supplements: What Are the Physiological Effects?
On the website they say this though:Good summary:
" The higher dose of T2 used was 80 times that of T3. Thus, it allows for its estimated lower affinity for the TH receptors, assuming that the affinity of T3 for the receptors is indeed 100 times that of T2 (8). This high dose of T2 essentially mimicked all the physiological effects obtained with the T3 dose. These effects included suppression of the HPT axis, decreases in fat mass, serum leptin and cholesterol, and increases in lean mass, food intake, and hepatic expression of TH-dependent genes relevant to lipid metabolism (see summary of results in Table 1). After 4 weeks, this high dose of T2 also caused cardiac hypertrophy and resulted in elevated metabolic rate and body temperature. These results demonstrate that at a dose that corrects for its decreased affinity for the TH receptor, T2 is capable of producing the same biological effects as T3."
Cardiac Hypertrophy? This cannot be a good thing?Good summary:
" The higher dose of T2 used was 80 times that of T3. Thus, it allows for its estimated lower affinity for the TH receptors, assuming that the affinity of T3 for the receptors is indeed 100 times that of T2 (8). This high dose of T2 essentially mimicked all the physiological effects obtained with the T3 dose. These effects included suppression of the HPT axis, decreases in fat mass, serum leptin and cholesterol, and increases in lean mass, food intake, and hepatic expression of TH-dependent genes relevant to lipid metabolism (see summary of results in Table 1). After 4 weeks, this high dose of T2 also caused cardiac hypertrophy and resulted in elevated metabolic rate and body temperature. These results demonstrate that at a dose that corrects for its decreased affinity for the TH receptor, T2 is capable of producing the same biological effects as T3."
My thoughts too. It is believed that at the proper dose this is not a concern, but they dose that might induce this hypertrophy is too close IMHO. I need more data and more evidence before I can recommend T2. Promising, yes! Let's see more!Cardiac Hypertrophy? This cannot be a good thing?
To an extant this the newest shiny thing and it’s becoming more available so there is some hype. That’s far from the full story of course. T2 promises increased metabolic rate, weight loss and possibly browning of white fat cells with relatively low side effects. So, the interest seems warranted.How long has thyroid been studied and no one ever talked about T2 before? All this makes me wonder if this isn't just a new, shiny penny.
T4/T3 combinations are available as a standard off the shelf prescription product (more common outside the US). And combinations of T4/T3 are available from compounding pharmacies in the US. As is an extended release T3 form some compounding pharmacies (that’s sort of unusual otherwise).Thank you, @AspiringSage. This may be a dumb question but is T2 available in an Rx combination (e.g., T4/T3/T2) or can it only be supplemented?
It bugs me that this is not a standard off the shelf prescription in the US and that doctors are so poorly educated about the depth, breadth, and importance of a functioning thyroid. But I know this is no accident.T4/T3 combinations are available as a standard off the shelf prescription product (more common outside the US). And combinations of T4/T3 are available from compounding pharmacies in the US. As is an extended release T3 form some compounding pharmacies (that’s sort of unusual otherwise).
With respect to combinations of T4/T3/T2 I’ve never seen a script for the combination. Mainstream docs are going out on a limb prescribing something that’s not an approved drug or a widely used supplement. I am sure there are some functional medicine providers who are ahead of the curve. But generally T2 is going to be supplement territory in the US and I am not familiar with any widespread use in the rest of the world.