TruffleGnocchi
Member
Tadalafil: Erectile Dysfunction Cure? Testosterone Booster? Non-Responders? [Study 147-154 Analysis]
View: https://www.youtube.com/watch?v=Nmi3hR9aA80
Interesting video explaining the actual mechanisms of Tadalafil, Nitric Oxide inhibiting Calcium uptake of cells and accelerated Potassium release from cells, and the mechanism for potential increased Testosterone production effect of Tadalafil. There is graphics of molecules and timestamps.
At 8:11 he explains the mechanism of how Tadalafil inhibits calcium influx into cells and into some non-cell structure in muscles, and also accelerates release of potassium, leading to relaxation of the cells, which allows for vasodilation.
At 15:52 the mechanism for potential Testosterone production increase of Tadalafil.
He also says Testosterone itself can increase Nitric Oxide production. Not sure if this is true. At 13:40 min
At 36:11 he goes through a graph from a study that shows Tadalafil significantly decreases Estrogen and significantly increases insulin levels. Though he says the study is not that good because there was no placebo group.
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On the topic of Nitric Oxide. I heard that the nose produces nitric oxide when nose breathing, allegedly to act as a disinfectant of the air inhaled through the nose.
If this is true, could Nitric Oxide act as a systemic anti-microbial? Maybe the anti-microbial effects would outweigh it's negative effects? Maybe a non-chronic, periodical acute increases of Nitric Oxide could clear the body of some pathogens. Maybe pathogens are worse for the body than the Nitric Oxide amount required to kill them. I guess that would depend on how effective it is as an antimicrobial and in what amounts to make an educated guess if it is positive or not.
View: https://www.youtube.com/watch?v=Nmi3hR9aA80
Interesting video explaining the actual mechanisms of Tadalafil, Nitric Oxide inhibiting Calcium uptake of cells and accelerated Potassium release from cells, and the mechanism for potential increased Testosterone production effect of Tadalafil. There is graphics of molecules and timestamps.
At 8:11 he explains the mechanism of how Tadalafil inhibits calcium influx into cells and into some non-cell structure in muscles, and also accelerates release of potassium, leading to relaxation of the cells, which allows for vasodilation.
At 15:52 the mechanism for potential Testosterone production increase of Tadalafil.
He also says Testosterone itself can increase Nitric Oxide production. Not sure if this is true. At 13:40 min
At 36:11 he goes through a graph from a study that shows Tadalafil significantly decreases Estrogen and significantly increases insulin levels. Though he says the study is not that good because there was no placebo group.
------------------------------------------------------------------
On the topic of Nitric Oxide. I heard that the nose produces nitric oxide when nose breathing, allegedly to act as a disinfectant of the air inhaled through the nose.
If this is true, could Nitric Oxide act as a systemic anti-microbial? Maybe the anti-microbial effects would outweigh it's negative effects? Maybe a non-chronic, periodical acute increases of Nitric Oxide could clear the body of some pathogens. Maybe pathogens are worse for the body than the Nitric Oxide amount required to kill them. I guess that would depend on how effective it is as an antimicrobial and in what amounts to make an educated guess if it is positive or not.
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