ddjd
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- Joined
- Jul 13, 2014
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For those of you who don't know, 11β-HSD1, is the enzyme that converts cortisone into active cortisol.
In our peatosphere, there are many substances hailed for their incredible 11β-HSD1 inhibiting effects due to their cortisol lowering action. For example:
Coffee (Coffee Inhibits Cortisol Synthesis)
Emodin (Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice)
Aspirin
Vitamin A retinol
Niacinamide (The Anti-cortisol Effects Of Niacinamide)
palmitic acid/ saturated fat
Progesterone
the 11β-HSD1 enzyme has been identified as regulating cortisol production in adipose tissue and as we are constantly told, cortisol is the key culprit when it comes to belly fat.
My query is why do all the things in that list above, that inhibit 11β-HSD1 and therefore lower cortisol, cause me significant increased bloating and belly fat. We're told cortisol is the cause of belly fat, but by inhibiting 11β-HSD1 and "lowering cortisol", my belly fat only increases.
As a "**** it" experiment I tried taking T4 thyroid only (levothyroxine) which is known for the opposite effect, of agonising 11β-HSD1 , so increasing free cortisol. What was the result....my belly shrunk to a normal size, within 20 minutes. I've tested this over 10 times now and every time with the same effect after a big meal.
So i tested another product, Licorice, which also agonises 11β-HSD1, and increases free cortisol, like T4. Again, after a big meal, my belly bloating reduced. Lastly i tested hydrocortisone 5mg, after a meal, and got complete confirmation - belly size much flatter!
When I take niacinamide, retinol, progesterone, saturated fat, or any of the cortisol lowering 11β-HSD1 antagonists, as i have for five years now, my belly bloating always increases.
go figure...
even more interesting, Testosterone UPREGULATES the 11β-HSD1 enzyme, so testosterone increases cortisol. What's the one thing everyone on TRT benefits from - huge reduction in belly fat!
"Testosterone significantly upregulated 11β-HSD-1 mRNA expression "
Testosterone increases 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) expression in the rat heart | SFEBES2009
In our peatosphere, there are many substances hailed for their incredible 11β-HSD1 inhibiting effects due to their cortisol lowering action. For example:
Coffee (Coffee Inhibits Cortisol Synthesis)
Emodin (Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice)
Aspirin
Vitamin A retinol
Niacinamide (The Anti-cortisol Effects Of Niacinamide)
palmitic acid/ saturated fat
Progesterone
the 11β-HSD1 enzyme has been identified as regulating cortisol production in adipose tissue and as we are constantly told, cortisol is the key culprit when it comes to belly fat.
My query is why do all the things in that list above, that inhibit 11β-HSD1 and therefore lower cortisol, cause me significant increased bloating and belly fat. We're told cortisol is the cause of belly fat, but by inhibiting 11β-HSD1 and "lowering cortisol", my belly fat only increases.
As a "**** it" experiment I tried taking T4 thyroid only (levothyroxine) which is known for the opposite effect, of agonising 11β-HSD1 , so increasing free cortisol. What was the result....my belly shrunk to a normal size, within 20 minutes. I've tested this over 10 times now and every time with the same effect after a big meal.
So i tested another product, Licorice, which also agonises 11β-HSD1, and increases free cortisol, like T4. Again, after a big meal, my belly bloating reduced. Lastly i tested hydrocortisone 5mg, after a meal, and got complete confirmation - belly size much flatter!
When I take niacinamide, retinol, progesterone, saturated fat, or any of the cortisol lowering 11β-HSD1 antagonists, as i have for five years now, my belly bloating always increases.
go figure...
even more interesting, Testosterone UPREGULATES the 11β-HSD1 enzyme, so testosterone increases cortisol. What's the one thing everyone on TRT benefits from - huge reduction in belly fat!
"Testosterone significantly upregulated 11β-HSD-1 mRNA expression "
Testosterone increases 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) expression in the rat heart | SFEBES2009
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