Peata
Member
- Joined
- Jun 12, 2013
- Messages
- 3,402
I am going to just come out and ask since I'm not finding satisfactory answers in my searches. I know Benadryl reduces histamine, so that's good. But what is it doing with serotonin?
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Mittir said:The link you provided used a graph of Benadryls receptor occupancy profile and there is the
source below that chart. He did not provide the whole chart. At the bottom of the original chart
they added 150-300 mg for antidepressant and 1-6 mg for hypnotic activity. Here is the link
http://www.cnsspectrums.com/userdocs/ar ... ig6big.jpg
I have used few times Benadryl for sleep and i found about 2.5 mg dose helped me sleep without
next day drowsiness and that fits with their findings. They did not talk about anti-histamine dose.
You get an idea that beyond 150 mg Benadryl starts acting as SSRI.
I have had bad allergy for a long time and only thing that surely working is
following RP style eating and very recently i have found out that large calcium
intake keeps histamine in check. I take about 2000 mg of calcium and make
sure phosphorus is lower than calcium. If you have chronic allergy problem
then diet is the only way to solve this problem. Because all these anti-histamine
can only help with mild allergy without causing more irritating side effects.
I have used all kind of anti allergy meds, they cause more problems than they solve.
RP also commented that all antiserotonergic med has side effects
Charlie said:Mittir, do you supplement calcium and if so what do you use?
Peata said:Thank you again, Mittir. Lots of great info in your posts.
Mittir said:The link you provided used a graph of Benadryls receptor occupancy profile and there is the
source below that chart. He did not provide the whole chart. At the bottom of the original chart
they added 150-300 mg for antidepressant and 1-6 mg for hypnotic activity. Here is the link
http://www.cnsspectrums.com/userdocs/ar ... ig6big.jpg
I have used few times Benadryl for sleep and i found about 2.5 mg dose helped me sleep without
next day drowsiness and that fits with their findings. They did not talk about anti-histamine dose.
You get an idea that beyond 150 mg Benadryl starts acting as SSRI.
I have had bad allergy for a long time and only thing that surely working is
following RP style eating and very recently i have found out that large calcium
intake keeps histamine in check. I take about 2000 mg of calcium and make
sure phosphorus is lower than calcium. If you have chronic allergy problem
then diet is the only way to solve this problem. Because all these anti-histamine
can only help with mild allergy without causing more irritating side effects.
I have used all kind of anti allergy meds, they cause more problems than they solve.
RP also commented that all antiserotonergic med has side effects
6 mg? I don't feel anything until at least 60.My understanding of the paper you cited is that they think within
hypnotic range of 1-6 mg Benadryl only acts on H1 receptor, above that
it starts working on M1, which causes dry mouth, confusion etc.
Based on that safest dose to lower histamine is below 6 mg.