Several other drugs achieved similar effects, but caffeine did best in extending both average and maximal lifespan. I have not seen any other naturally found compound come even close to extending life by so much. The human dosage equivalent according to the researchers is 100mg-200mg every 4h, so this would be 600mg-1200mg per day. Here are some studies:
FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity
Caffeine extends yeast lifespan by targeting TORC1. - PubMed - NCBI
Keep in mind this was pure caffeine study, not coffee or any other drink containing caffeine. So, in theory caffeine pills should be the way to go for replication, but I am sure coffee won't hurt either given its other good compounds.
FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity
Caffeine extends yeast lifespan by targeting TORC1. - PubMed - NCBI
Keep in mind this was pure caffeine study, not coffee or any other drink containing caffeine. So, in theory caffeine pills should be the way to go for replication, but I am sure coffee won't hurt either given its other good compounds.
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