miko said:I can't test pregnenolone in the place I live. My DHEA is 5,8 (1,8-12,5) - and a few years ago it was above limit. My prolactin is 5,14 (4,04-15,2).
There isn't any indications from tests. My cortisol is high but in the limit - 446 (171-536) but I have many signs of elevated cortisol. I think my cortisol is from stress and depression (and my depression is from stress). I need some drug to calm my HPA axis and mind. I have tried almost all antidepressants without success (the only one with some reaction is mirtazapine and this drug lowers cortisol to some point). My other symptoms are acne, very oily skin, balding, low immune system. I'm thinking about progesterone becouse it's lowers cortisol and could help with my skin/hair problems (it's 5-alpha reductase inhibitor). I don't need libido in my situation... My estrogens in blood are not high but I have some breast enlargement - I have tried progesterone for a few days and my breast quickly decreased (only for a few days becouse I wanted to check my progesterone levels in blood) - I was thinking that when my cortisol, 17-oh progesterone, and androstenedione is quite high (17-oh prog- 1,31 (0,05-1,6), androstenedione-3 (0,7-3,6), so my progesterone would be high (to produce more of it's successors like 17-oh prog, and cortisol), but my progesterone is 0,23 (0,2-1,4). So i'm thinking about "stealing problem" like a real issue. I think that request for cortisol and other successors of progesterone is so high in my body that my progesterone level is "exhausted" and progesterone (and it's metabolites) couldn't work for me (so it's skin/hair problems etc.) Maybe some progesterone from supplementation could solve some of my problems with skin/hair and additionally lower my cortisol/HPA axis activity.
What do you think?
PS. RU486 is progesterone antagonist (Peat writes something about this drug and cancer).
Well, not sure what to tell you. I guess you can try some pregnenolone and do some blood tests. Some people have really good experience with Relora and as far as the studies show it does not affect hormones. Theanine in larger doses also calms down the HPA axis.