AretnaP
Member
- Joined
- Mar 27, 2017
- Messages
- 180
Human height may be more genetic than once assumed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34445/
Estrogen treatment caused fusion to occur earlier at all three anatomical sites studied. That estrogen accelerated both senescence and fusion suggests that these two processes are linked; fusion may be triggered when the senescence program advances to a certain critical point. Thus, estrogen may not stimulate fusion directly. Instead, it may simply accelerate the senescence program, thus secondarily triggering fusion earlier. In particular, fusion occurred at approximately the same time that the proliferation rate approached zero. This temporal association, which was observed at all anatomical sites studied and in both treatment groups, suggests that fusion is triggered when the proliferative potential of the growth plate chondrocytes is finally exhausted. Estrogen, by accelerating senescence, may hasten proliferative exhaustion and thus cause earlier fusion. This model would explain why estrogen affected growth plate function and structure promptly, whereas the effect on fusion was more delayed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34445/