Douglas Ek
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- Feb 8, 2017
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17β-Estradiol Inhibits Iron Hormone Hepcidin Through an Estrogen Responsive Element Half-Site
”Hepcidin is the central regulatory molecule of systemic iron homeostasis (5). In this study, we found that hepcidin mRNA is inhibited in cells and in mice by nanomolar concentrations of E2 (Figs. 2 and and5),5), which is physiologically or pharmacologically relevant to young women at the preovulatory phase or those taking a contraceptive.”
According to this study, E2 affects hepcidin production. High E2 significantly inhibits hepcidin production thus leading to higher iron absorption from the diet. The connection seems clear and thus lowering/inhibiting estrogen would be beneficial for people with elevated ferritin. Also since vitamin E and aspirin seems to be able to lower iron this might be through its effect of lowering estrogen thus increasing hepcidin production. Or its a combination of things. Also, people with low estrogen might be more susceptible to get anemia. Men with low testosterone would equal low estrogen and thus might result in depletion of iron stores. Just a thought.
Same goes for estrogen and copper. Estrogen increases copper absorption. Zinc is an estrogen inhibitor and been shown to deplete both iron and copper levels.
”Hepcidin is the central regulatory molecule of systemic iron homeostasis (5). In this study, we found that hepcidin mRNA is inhibited in cells and in mice by nanomolar concentrations of E2 (Figs. 2 and and5),5), which is physiologically or pharmacologically relevant to young women at the preovulatory phase or those taking a contraceptive.”
According to this study, E2 affects hepcidin production. High E2 significantly inhibits hepcidin production thus leading to higher iron absorption from the diet. The connection seems clear and thus lowering/inhibiting estrogen would be beneficial for people with elevated ferritin. Also since vitamin E and aspirin seems to be able to lower iron this might be through its effect of lowering estrogen thus increasing hepcidin production. Or its a combination of things. Also, people with low estrogen might be more susceptible to get anemia. Men with low testosterone would equal low estrogen and thus might result in depletion of iron stores. Just a thought.
Same goes for estrogen and copper. Estrogen increases copper absorption. Zinc is an estrogen inhibitor and been shown to deplete both iron and copper levels.
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