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@Blossom (thanks for the tag)For excess serotonin in the body, I don't know where to begin in terms of safe (minimal) effective dosage, what form (brand?)
Liquid - capsule - powder...??
I need to add something. There are several high serotonin foods that you will need to avoid, at least for a while. Bananas and pineapple are on the list to avoid. They used to really mess me up. Now I can eat bananas without any problems.For excess serotonin in the body, I don't know where to begin in terms of safe (minimal) effective dosage, what form (brand?)
Liquid - capsule - powder...??
Where to purchase/What Brand is good, reliable?- Whole Foods? Vitamin Mart?@Blossom (thanks for the tag)
@DMF My personal experience with thiamine supplementation was mainly with thiamine hcl. It seems to have the longest track record and is considered a "safe" supplement. It tastes terrible but you get used to it over time. I did try TTFD thiamine, but I reacted badly to it because I was deficient in glutathione so I went back to using thiamine hcl. I also tried the sublingual thiamine mononitrate but I didn't like how I reacted to it (worse short term memory); this could have been psychosomatic because of the "nitrate" part of the name. I'm very sensitive to nitrates. I've taken high dose thiamine hcl for almost 2 years and am very happy with the results.
I use the pure powder form of thiamine hcl (sold in bulk by bulksupplement.com, also available from purebulk.com); you can measure out exactly the amount your want so increasing your dose over a few weeks is pretty easy. Get a little digital scale so you can weigh out little doses; also get a set of tiny measuring spoons to make dosing fast/easy for daily use.
I was taking 100mg of thiamine hcl 2Xday for years, but I took it with orange juice which canceled out the thiamine's effect. When I found myself in serious trouble due to thiamine deficiency/functional blockage, I tried taking about 300mg of thiamine hcl with WATER and within 45 minutes, all my lactic acidosis inflammation pain disappeared and my body temp increased a full degree up to normal (98.6). This is how I discerned that I had a problem with thiamine deficiency/functional blockage. I spent the next 4 months slowly increasing my dose of thiamine hcl from 300mg 2Xday to 1 gram 2Xday. At first the next higher dose would resolve my symptoms but after 7-10 days, the dose would not work so well so I would increase it again. I relied on my own response to the vitamin. I also supplemented with magnesium glycinate and several other b vitamins (not high doses of the other b's). If you are deficient in magnesium you may have more trouble taking thiamine hcl. I was deficient in it and I still take a pretty high dose of magnesium glycinate today.
Thiamine hcl has to be taken in higher doses than some other forms of thiamine (TTFD) because it doesn't get through the gut barrier very efficiently. Dr. Costantini's website includes comparison information of oral thiamine hcl vs injection thiamine hcl. I found the information on his website very helpful and informative (therapy, FAQs, and patient videos).
I hope you find this helpful.
Amen to that. I took the powder for years but eventually could no longer get it past my palate.It tastes terrible
I agree that there are downsides to each type of thiamine that is available. I think it is important for people to learn about the different types and experiment to find what works for them.Amen to that. I took the powder for years but eventually could no longer get it past my palate.
I switched to allithiamine. Only downside is it's more expensive. But if you figure the cost on a "per absorbed milligram" basis I'd bet it's not actually any more expensive (though I have not done the calculations).
Also if you want higher dosage, it may be that the HCL is ineffective. For many chemicals that are poorly absorbed, absorption percentage falls off with increasing dosage. As an extreme example if 10% is absorbed with a low dose, but only 5% is absorbed with twice that dose, you would not be getting any more by doubling the dose. Allithiamine absorbs well so I can get the carbonic anhydrase inhibitor effect at higher doses without resorting to injections, as would be necessary with HCL.
I can't answer that, but clearly anyone with a known glutathione issue should probably research first. In your case it might very well be best to just stick with HCL. If it ain't broke...Allithiamine?) utilizes glutathione
I've tried TTFD and also sublingual thiamine mononitrate and I keep coming back to the hcl variety. It does work for me. Not broke (thank goodness for that!).I can't answer that, but clearly anyone with a known glutathione issue should probably research first. In your case it might very well be best to just stick with HCL. If it ain't broke...
Did you heal your gut issues and bloating with this treatment, right?I've tried TTFD and also sublingual thiamine mononitrate and I keep coming back to the hcl variety. It does work for me. Not broke (thank goodness for that!).
I healed my gut issues with thiamine hcl, plus a healthy diet made up principally of dairy, fruit, gelatin, cooked mushrooms, lots of cooked mushrooms. I think the magnesium glycinate helped too. The thiamine hcl massively improved my digestive tract, including my stomach acid and peristalsis.Did you heal your gut issues and bloating with this treatment, right?
Inspiring experience. So, do you eat a starch free diet?I healed my gut issues with thiamine hcl, plus a healthy diet made up principally of dairy, fruit, gelatin, cooked mushrooms, lots of cooked mushrooms. I think the magnesium glycinate helped too. The thiamine hcl massively improved my digestive tract, including my stomach acid and peristalsis.
I'm gluten sensitive so I don't eat grains, maybe a little oatmeal once in a while. I do eat white potatoes 2-3 times a week. That's about it for starch. I take it back; I eat a little white rice once in a while, maybe 2Xmonth.Inspiring experience. So, do you eat a starch free diet?
Omg, I can't go without starch, I crave It 24/7.I'm gluten sensitive so I don't eat grains, maybe a little oatmeal once in a while. I do eat white potatoes 2-3 times a week. That's about it for starch. I take it back; I eat a little white rice once in a while, maybe 2Xmonth.
Maybe you're onto something.... My gut got really messed up after three rounds of various antibiotics summer of 2020 (bladder infection). The Bactrim antibiotic blocked my thiamine function; I was already low in it because of the heavy metal poisoning so I really got slammed by the bactrim. I was very sick for months. There are a lot of antibiotics that work by blocking thiamine function to kill the bacteria that need it to survive.Omg, I can't go without starch, I crave It 24/7.
I wonder if these cravings are due to the microbiota since they don't occur to me when I was younger, before I had taken four diferent rounds of antibiotics.
How did pineapple mess you up? I have been eating 1-3 whole ones each day. Maybe I am lacking the self awareness to notice the damage it's causing. I'm utterly addicted to these honeyglow pineapples... I wish I was kidding.I need to add something. There are several high serotonin foods that you will need to avoid, at least for a while. Bananas and pineapple are on the list to avoid. They used to really mess me up. Now I can eat bananas without any problems.
from 18 Foods That Contain Serotonin | Livestrong.com Ignore the hype about how great serotonin is but do pay attention to the list of foods:
also:
- Bananas
- Kiwi
- Plantains
- Pineapple
- Passion fruit
- Pomegranate
- Strawberries
- Plums
- Chicory
- Chinese cabbage
- Green onion
- Lettuce
- Peppers
- Potatoes
- Spinach
- Tomatoes
- Wild rice
- Hazelnuts
It made me attach myself to the ceiling using my fingernails. I was keyed up, could not relax, could not sleep. High serotonin reaction.How did pineapple mess you up? I have been eating 1-3 whole ones each day. Maybe I am lacking the self awareness to notice the damage it's causing. I'm utterly addicted to these honeyglow pineapples... I wish I was kidding.