OP
JerkyPerky
Member
- Joined
- Jul 17, 2018
- Messages
- 20
Possibly? I need to read up on how nitric oxide effects blood flow/vessels.The mononitrate will boosts nitric oxide, which is not good. Maybe this is causing issues?
UPDATE:
Okay, so completely cutting out salt solved the problem with the black spots completely! I believe the swelling of my liver is somewhat relieved as well since the pressure in my right side was somewhat lighter this morning. I went from about 6-8 g salt down to 1 g and will keep it there for a while and see how I progress.
I believe I've read on this forum earlier how vitamin A toxicity has an effect on membrane stability or something. This could definitely be the case. Enabling diffusion of sodium into hepatocytes/disrupting the N+kinase pumps function --> cell swelling --> loss of liver function distrupting thrombopoietin synthesis/fluid shear stress destroying platelets --> excacerbated thrombocytopenia?????
Retinol/retinoids' effect on membranes I can't fully grasp, but the sodium retention seems like a real issue.
"The hypervitaminosis A, confirmed by a significant increase in tissue concentration of the vitamin, altered the hepatic content of the above mentioned cations. While Na and Zn increased..."
Effects of acute overdose of vitamin A on the hepatic content of K, Na, Mg, Fe, Cu and Zn, in rats. - PubMed - NCBI
"The harmful effect of an excess of the vitamin A was manifested in an increased content of Na+ in erythrocytes and also in decreased stability of the cells to acid hemolytics."
Effects of acute overdose of vitamin A on the hepatic content of K, Na, Mg, Fe, Cu and Zn, in rats. - PubMed - NCBI
"These results suggest that retinoid toxicity may indeed be related to a membrane effect"
Membrane effects of retinoids: Possible correlation with toxicity - ScienceDirect
"Hypervitaminosis A induces the following changes in rat kidney: decrease in sodium and potassium excretion and an increase of urinary volume."
Changes in sodium and potassium excretion and urinary volume in rats submitted to hypervitaminosis A. - PubMed - NCBI
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