Can you show me the research that shows effexor switches off oxidative metabolism I would be interested to see it, do other anti depressants do this as well? Asking because my brother is on sertraline which I know is not good for him.Do everything you possibly can to get her off the Effexor. That's the main cause probably. Switching her to torpor instead of oxidative metabolism. I quit Lexapro cold turkey when I was young. It's not dangerous if you use cyproheptadine.