Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
http://www.ncbi.nlm.nih.gov/pubmed/23809162
NLRP3 activates the proinflammatory cytokine IL-1, and also activates caspase-1, this results in the progression of many (most?) diseases. Cholesterol crystals activate NLRP3 when they are oxidized (estrogen probably plays a role in this, as well as other forms of stress).
Example of NLRP3 in disease :
http://www.nature.com/nature/journal/va ... bal=remove
"Nlrp3−/− or Casp1−/− mice carrying mutations associated with familial Alzheimer’s disease were largely protected from loss of spatial memory and other sequelae associated with Alzheimer’s disease, and demonstrated reduced brain caspase-1 and interleukin-1β activation as well as enhanced amyloid-β clearance."
I think if you're gonna eat 4g of Pufas, it might as well be Omega-3's (and using Vit E/aspirin would probably prevent prostaglandin production).
The additional strategy is to increase the anti-inflammatory cytokine IL-10, which downregulates NLRP3. Pregnenolone/Dhea/Progesterone, adiponectin, testosterone, Hdac inhibitors, Butyrate, ethanol (also inhibit NLRP3), sun light, exercise, Cayenne pepper, Nad+, cAMP, increase IL-10.
http://www.ncbi.nlm.nih.gov/pubmed/23809162
NLRP3 activates the proinflammatory cytokine IL-1, and also activates caspase-1, this results in the progression of many (most?) diseases. Cholesterol crystals activate NLRP3 when they are oxidized (estrogen probably plays a role in this, as well as other forms of stress).
Example of NLRP3 in disease :
http://www.nature.com/nature/journal/va ... bal=remove
"Nlrp3−/− or Casp1−/− mice carrying mutations associated with familial Alzheimer’s disease were largely protected from loss of spatial memory and other sequelae associated with Alzheimer’s disease, and demonstrated reduced brain caspase-1 and interleukin-1β activation as well as enhanced amyloid-β clearance."
I think if you're gonna eat 4g of Pufas, it might as well be Omega-3's (and using Vit E/aspirin would probably prevent prostaglandin production).
The additional strategy is to increase the anti-inflammatory cytokine IL-10, which downregulates NLRP3. Pregnenolone/Dhea/Progesterone, adiponectin, testosterone, Hdac inhibitors, Butyrate, ethanol (also inhibit NLRP3), sun light, exercise, Cayenne pepper, Nad+, cAMP, increase IL-10.