Progesterone/Pregnenolone mixed withsaated fats for ingestion

[Happycat]

Editing... don't know how to correct the title, it got saved too quickly.

In the last Dr Mercola Georgi interview about serotonin and estrogen, 22 October 2023, they were talking about taking pregnenolone or progesterone and mixing it with a saturated fat, to avoid the first pass through the liver.

Dr Mercola was talking about mixing pregnenolone with butter and ingesting it. Also mixing it with cocoa butter and making it into a suppository.

But I'm not sure they meant this can also be done with progesterone, such as Prometrium, which gets destroyed by the first pass through the liver?
Anyone know?

 

[mostlylurking]

Editing... don't know how to correct the title, it got saved too quickly.

In the last Dr Mercola Georgi interview about serotonin and estrogen, 22 October 2023, they were talking about taking pregnenolone or progesterone and mixing it with a saturated fat, to avoid the first pass through the liver.

Dr Mercola was talking about mixing pregnenolone with butter and ingesting it. Also mixing it with cocoa butter and making it into a suppository.

But I'm not sure they meant this can also be done with progesterone, such as Prometrium, which gets destroyed by the first pass through the liver?
Anyone know?

Ray Peat talked about rubbing progesterone (that has been dissolved in vitamin E, like Progest-E) into your gums (or vaginal tissues) because then it would be absorbed quickly through that tissue, go directly into the blood stream, and miss that first pass through the liver.

go here: bioenergetic search, search for progesterone tissue gums