md_a
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- Joined
- Aug 31, 2015
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- 468
The capillary defect is produced by an interaction of inflammatory cells and mediators, including leukocytes, cytokines, oxygen radicals, complement and arachidonate metabolites, that damages the endothelium and allows fluid and proteins to leak.
Adult Respiratory Distress Syndrome (ARDS)
Maybe less PUFA means less need for iodine. PUFA is involved in inflammation – ARDS
COVID-19/SARS may be due simply to serum PUFA and its peroxidation
COVID-19/SARS may be due simply to serum PUFA and its peroxidation – To Extract Knowledge from Matter
…
Polyunsaturated fats – In Food, In Everything
Using iodine is one of the methods for determining how unsaturated an oil is. The number of grams of iodine absorbed by 100 grams of a given oil is called the iodine value. You can read about it more on Wikipedia here. The more unsaturated the more iodine it absorbs – some very unsaturated oils actually absorb more grams of iodine than their own mass.
Unsaturated fatty acids are the those containing carbon-carbon double bonds. Iodine atoms react across the carbon-carbon bonds. The iodine will attach itself over a double bond to make a single bond where an iodine atom is now attached to each carbon atom. Higher iodine numbers do not refer to the amount of iodine in the oil, but rather the amount of iodine needed to “saturate” the oil, or break all the double bonds (23). Therefore, the more unsaturated, the more iodine it takes to break all the double bonds.
Most Peat-arians know the value of Saturated oils – those without double-bonds that resist becoming peroxides or hydrogenated at high temperatures. They are also are well-versed in the dangers associated with high polyunsaturated fat intake due to their effects on the thyroid gland, inflammation, and blood sugar metabolism. Every gram of our favorite soybean oil absorbs between 1.2 and 1.36 grams of iodine. Yes, you read that right. 1.36 GRAMS! (19)
Linoleic Acid Becomes Similar to Stearic Acid
Linoleic Acid Becomes Similar to Stearic Acid
This means if my body is 20% body fat (18 kilograms), let’s be generous and say that it is 40% fully saturated (similar to cocoa butter – see table here), my body fat is capable of absorbing 18,000 grams * .40 = 7200 grams of iodine. If I were fully made up of our good friend coconut oil, my body fat would only absorb 18,000 *.12 = 2160 grams of iodine. This example may be a red herring, but it goes to show that essentially the more fat you eat, especially the more unsaturated fat you eat, the more iodine you may need in your diet.
Iodine Revisited: Is There Something There? - Scott Schlegel
Iodine value - Wikipedia
“One of the best-known free radical scavenging substances that has been widely used as a drug is iodide. It has been used to treat asthma, parasites, syphilis, cancer, Graves’ disease, periodontal disease, and arteriosclerosis. Diseases that produce tissue overgrowth associated with inflammation--granulomas--have been treated with iodides, and although the iodide doesn’t necessarily kill the germ, it does help to break down and remove the granuloma. Leprosy and syphilis were among the diseases involving granulomas* that were treated in this way. In the case of tuberculosis, it has been suggested that iodides combine with unsaturated fatty acids which inhibit proteolytic enzymes, and thus allow for the removal of the abnormal tissue.
In experimental animals, iodide clearly delays the appearance of cataracts. (Buchberger, et al., 199l.)
Inflammation, edema, and free radical production are closely linked, and are produced by most things that interfere with energy production.
Endotoxin, produced by bacteria, mainly in the intestine, disrupts energy production, and promotes maladaptive inflammation. The wide spectrum of benefit that iodide has, especially in diseases with an inflammatory component, suggests first that it protects tissue by blocking free radical damage, but it also suggests the possibility that it might specifically protect against endotoxin.”
The simplest way to visualize the effect of carbon dioxide on mucopolysaccharides is to think of its action as an expectorant, in which it decreases the viscosity of bronchial mucus, allowing it to be reabsorbed or expelled. Since iodide also has a long history of use as an expectorant, we should compare the effects of carbon dioxide and carbonic acid with the effects of iodide in other situations.
The sea cucumber has been used to study the physical properties of connective tissue, and it has been found that certain salts tend to soften the connective tissues, but that iodide doesn't. The well-established use of iodide to resolve granulomas, even when it doesn't eliminate the infectious agent, might suggest that it is protecting against something which is disrupting the connective tissue structure. The only publications I have seen that presented clear evidence of the disappearance of arteriosclerosis involved treatment with iodides.
In the retina, blood vessels can be seen to return to their normal appearance following a course of iodide treatment. Besides its possible direct effects on the mucins, iodide might help to eliminate calcium from the walls of blood vessels, since calcium iodide is very soluble. In aging, connective tissue becomes hardened by chemical cross-linking of the large molecules. If amino groups are well saturated with carbon dioxide, this type of reaction should be inhibited (Carbon dioxide also inhibits the production of free radicals, which are involved in some types of cross-linking reactions.) The waterlogged condition seen during shock or stress in blood vessels, lungs, and other organs, and the edema of the brain and cataracts of the lenses that follow metabolic impairments of various sorts, seem to involve the uptake of "free" water, at the same time that "bound" (unfreezable) water is lost.
Carbon dioxide seems to promote the retention of bound water, and protects against the edematous conditions. The swelling of muscles during hypoxic stress probably represents the basic process, in which lactic acid and pH increase, while C02, is lost. - Ray Peat `MUCUS, MUCINS, AND MYOPIA`
…
Large doses of vitamin A and potassium iodide have been used separately and together to promote general immunity, also to treat fungus infections; I suspect that an effect of iodide is to protect against the toxicity of unsaturated fatty acids. - Ray Peat `IMMUNITY, HORMONES and YEAST INFECTION`
….
Other anti-thyroid foods are peanuts, soybeans, raw cabbage, radishes, broccoli, cauliflower, unsaturated oils (such as safflower, corn, cottonseed. and soy oils), and an excess of iodine. Amygdalin (nitrilosides, laetrile) which occurs in many nuts, seeds and grains, is also a thyroid inhibitor. Because iodate is used as a "dough conditioner" (to make bread water-heavy). the American eater often gets ten times more iodine than is recommended.
Combined with unsaturated oils, as organic iodides, excess iodine can powerfully inhibit the thyroid. Manganese is needed to synthesize thyroxin so, a deficiency an interfere with thyroid function (coffee is a major source of manganese. and caffeine also stimulates the thyroid). - Ray Peat
…
ARTERIOSCLEROSIS – Ray Peat
“The American Dietetic Association warns about overdosing with kelp. because of the iodide; but the Japanese eat various iodide-rich h seaweeds without the thyroid problems the A.D.A says might occur on the kelp-lecithin-vinegar B6 diet. In the U.S. people who eat bakery bread receive about 10 times more than the RDA of iodine. Iodides are known to benefit arteriosclerosis. with visible improvement occurring in blood vessels in the retina (see Physicians’ Desk Reference, iodides). In old age, the walls of blood vessels tend to become hardened with calcium. In at least some tissues, it is known that calcification begins in degenerating mitochondria, and mitochondria tend to deteriorate in aging tissue. Nutrients such as iodine, vitamin E, magnesium and vitamin B2 are especially important for maintaining the function of the mitochondria, which produce most of our energy. An excess of iodine from bread or kelp is much more likely to interfere with the thyroid when the diet contains a large amount of unsaturated fat. such as safflower or soy oil. because these combine with iodine to form substances which inhibit the thyroid. These oils in themselves suppress the thyroid, and this might be a factor in the premature aging and increased cancer rate which have been observed in people who use larger amounts of those oils.
Atherosclerotic damage (fatty deposits) of blood vessels is made worse by sugar supposedly, since insulin is involved in cholesterol damage. There is evidence that lecithin and other phospholipids protect the body against fatty degeneration.
Eggs for several reasons might actively protect against the formation of cholesterol deposits. One of the men who discovered insulin, Best, later showed that choline (a component of lecithin) can prevent fatty degeneration of the liver. Very large doses of biotin cause experimental animals to develop fatty livers (developing into liver cancer). but this effect can be offset by feeding the animal another B vitamin. inositol. Some of these effects have been known for about half a century, but too many " health professionals" are still pretending that no valid data exist. Maybe we should start asking whether these " health professionals" have a valid existence.”
….
The Myth of Iodine Deficiency: An Interview with Dr. Ray Peat
Is iodine supplementation safe and, if not, is there a safe amount of supplemental iodine?
Dr. Peat: “A dosage of 150 mcg (micrograms, not milligrams, e.g., ug not mg) is a safe amount of iodine. There are excellent references describing the effect of a moderate iodine excess (even below a milligram per day) on the thyroid. An iodine deficiency can cause hypothyroidism (rare now), but so can an excess. Iodine deficiency is an unusual cause of hypothyroidism, except in a few places, like the mountains of Mexico and China, and the Andes.
“Most goiters now are from estrogen-like effects, but they used to be from iodine deficiency. Chronic excess iodine tends to cause thyroiditis, regardless of the gland’s size. The amounts used by Abraham and Flechas are much larger than this — very toxic doses, enough to cause severe thyroid problems.”
Is the Iodine Test Kit (from Dr. Abraham) valid and does it reveal thyroid deficiency?
“Guy Abraham and some of his followers claim that an iodine deficiency can be shown by the quick disappearance of a spot of iodine painted on the skin. The skin test of iodine deficiency is completely unscientific. Iodine is converted to colorless iodide by reductants, including vitamin C, glutathione, and thiosulphate. “G. Abraham’s Iodine Test Kit contains iodine overdose pills. The test is completely irrational. It implies that the body should be saturated with iodine.”
Is there a rational way to determine iodine deficiency or excess?
“It’s easy to recognize a chronic iodine deficiency, because it causes the thyroid gland to enlarge. Goiters can be caused in various ways, for example by being exposed to various goitrogens, including excess iodine, or by excessive estrogen and deficient progesterone, as well as by an iodine deficiency. “However, a chronic excess of iodine is harder to recognize, because it can produce a variety of degenerative changes. Measurement of the average daily iodine intake or excretion in the urine would be needed to confirm an excess. High iodine intake can suppress TSH, and since high TSH is pro-inflammatory, the iodine can have some protective anti-inflammatory actions, but in the long run, the thyroid suppression becomes a problem.”
To Your Health – July 2008 by Lita Lee
Also:
Mary Shomon: Do you think the majority of people with hypothyroidism get too much or too little iodine? Should people with hypothyroidism add more iodine, like kelp, seaweeds, etc.?
Dr. Ray Peat: 30 years ago, it was found that people in the US were getting about ten times more iodine than they needed. In the mountains of Mexico and in the Andes, and in a few other remote places, iodine deficiency still exists. Kelp and other sources of excess iodine can suppress the thyroid, so they definitely shouldn’t be used to treat hypothyroidism.
https://www.functionalps.com/blog/2...ine-deficiency-an-interview-with-dr-ray-peat/
Adult Respiratory Distress Syndrome (ARDS)
Maybe less PUFA means less need for iodine. PUFA is involved in inflammation – ARDS
COVID-19/SARS may be due simply to serum PUFA and its peroxidation
COVID-19/SARS may be due simply to serum PUFA and its peroxidation – To Extract Knowledge from Matter
…
Polyunsaturated fats – In Food, In Everything
Using iodine is one of the methods for determining how unsaturated an oil is. The number of grams of iodine absorbed by 100 grams of a given oil is called the iodine value. You can read about it more on Wikipedia here. The more unsaturated the more iodine it absorbs – some very unsaturated oils actually absorb more grams of iodine than their own mass.
Unsaturated fatty acids are the those containing carbon-carbon double bonds. Iodine atoms react across the carbon-carbon bonds. The iodine will attach itself over a double bond to make a single bond where an iodine atom is now attached to each carbon atom. Higher iodine numbers do not refer to the amount of iodine in the oil, but rather the amount of iodine needed to “saturate” the oil, or break all the double bonds (23). Therefore, the more unsaturated, the more iodine it takes to break all the double bonds.
Most Peat-arians know the value of Saturated oils – those without double-bonds that resist becoming peroxides or hydrogenated at high temperatures. They are also are well-versed in the dangers associated with high polyunsaturated fat intake due to their effects on the thyroid gland, inflammation, and blood sugar metabolism. Every gram of our favorite soybean oil absorbs between 1.2 and 1.36 grams of iodine. Yes, you read that right. 1.36 GRAMS! (19)
Linoleic Acid Becomes Similar to Stearic Acid
Linoleic Acid Becomes Similar to Stearic Acid
This means if my body is 20% body fat (18 kilograms), let’s be generous and say that it is 40% fully saturated (similar to cocoa butter – see table here), my body fat is capable of absorbing 18,000 grams * .40 = 7200 grams of iodine. If I were fully made up of our good friend coconut oil, my body fat would only absorb 18,000 *.12 = 2160 grams of iodine. This example may be a red herring, but it goes to show that essentially the more fat you eat, especially the more unsaturated fat you eat, the more iodine you may need in your diet.
Iodine Revisited: Is There Something There? - Scott Schlegel
Iodine value - Wikipedia
“One of the best-known free radical scavenging substances that has been widely used as a drug is iodide. It has been used to treat asthma, parasites, syphilis, cancer, Graves’ disease, periodontal disease, and arteriosclerosis. Diseases that produce tissue overgrowth associated with inflammation--granulomas--have been treated with iodides, and although the iodide doesn’t necessarily kill the germ, it does help to break down and remove the granuloma. Leprosy and syphilis were among the diseases involving granulomas* that were treated in this way. In the case of tuberculosis, it has been suggested that iodides combine with unsaturated fatty acids which inhibit proteolytic enzymes, and thus allow for the removal of the abnormal tissue.
In experimental animals, iodide clearly delays the appearance of cataracts. (Buchberger, et al., 199l.)
Inflammation, edema, and free radical production are closely linked, and are produced by most things that interfere with energy production.
Endotoxin, produced by bacteria, mainly in the intestine, disrupts energy production, and promotes maladaptive inflammation. The wide spectrum of benefit that iodide has, especially in diseases with an inflammatory component, suggests first that it protects tissue by blocking free radical damage, but it also suggests the possibility that it might specifically protect against endotoxin.”
The simplest way to visualize the effect of carbon dioxide on mucopolysaccharides is to think of its action as an expectorant, in which it decreases the viscosity of bronchial mucus, allowing it to be reabsorbed or expelled. Since iodide also has a long history of use as an expectorant, we should compare the effects of carbon dioxide and carbonic acid with the effects of iodide in other situations.
The sea cucumber has been used to study the physical properties of connective tissue, and it has been found that certain salts tend to soften the connective tissues, but that iodide doesn't. The well-established use of iodide to resolve granulomas, even when it doesn't eliminate the infectious agent, might suggest that it is protecting against something which is disrupting the connective tissue structure. The only publications I have seen that presented clear evidence of the disappearance of arteriosclerosis involved treatment with iodides.
In the retina, blood vessels can be seen to return to their normal appearance following a course of iodide treatment. Besides its possible direct effects on the mucins, iodide might help to eliminate calcium from the walls of blood vessels, since calcium iodide is very soluble. In aging, connective tissue becomes hardened by chemical cross-linking of the large molecules. If amino groups are well saturated with carbon dioxide, this type of reaction should be inhibited (Carbon dioxide also inhibits the production of free radicals, which are involved in some types of cross-linking reactions.) The waterlogged condition seen during shock or stress in blood vessels, lungs, and other organs, and the edema of the brain and cataracts of the lenses that follow metabolic impairments of various sorts, seem to involve the uptake of "free" water, at the same time that "bound" (unfreezable) water is lost.
Carbon dioxide seems to promote the retention of bound water, and protects against the edematous conditions. The swelling of muscles during hypoxic stress probably represents the basic process, in which lactic acid and pH increase, while C02, is lost. - Ray Peat `MUCUS, MUCINS, AND MYOPIA`
…
Large doses of vitamin A and potassium iodide have been used separately and together to promote general immunity, also to treat fungus infections; I suspect that an effect of iodide is to protect against the toxicity of unsaturated fatty acids. - Ray Peat `IMMUNITY, HORMONES and YEAST INFECTION`
….
Other anti-thyroid foods are peanuts, soybeans, raw cabbage, radishes, broccoli, cauliflower, unsaturated oils (such as safflower, corn, cottonseed. and soy oils), and an excess of iodine. Amygdalin (nitrilosides, laetrile) which occurs in many nuts, seeds and grains, is also a thyroid inhibitor. Because iodate is used as a "dough conditioner" (to make bread water-heavy). the American eater often gets ten times more iodine than is recommended.
Combined with unsaturated oils, as organic iodides, excess iodine can powerfully inhibit the thyroid. Manganese is needed to synthesize thyroxin so, a deficiency an interfere with thyroid function (coffee is a major source of manganese. and caffeine also stimulates the thyroid). - Ray Peat
…
ARTERIOSCLEROSIS – Ray Peat
“The American Dietetic Association warns about overdosing with kelp. because of the iodide; but the Japanese eat various iodide-rich h seaweeds without the thyroid problems the A.D.A says might occur on the kelp-lecithin-vinegar B6 diet. In the U.S. people who eat bakery bread receive about 10 times more than the RDA of iodine. Iodides are known to benefit arteriosclerosis. with visible improvement occurring in blood vessels in the retina (see Physicians’ Desk Reference, iodides). In old age, the walls of blood vessels tend to become hardened with calcium. In at least some tissues, it is known that calcification begins in degenerating mitochondria, and mitochondria tend to deteriorate in aging tissue. Nutrients such as iodine, vitamin E, magnesium and vitamin B2 are especially important for maintaining the function of the mitochondria, which produce most of our energy. An excess of iodine from bread or kelp is much more likely to interfere with the thyroid when the diet contains a large amount of unsaturated fat. such as safflower or soy oil. because these combine with iodine to form substances which inhibit the thyroid. These oils in themselves suppress the thyroid, and this might be a factor in the premature aging and increased cancer rate which have been observed in people who use larger amounts of those oils.
Atherosclerotic damage (fatty deposits) of blood vessels is made worse by sugar supposedly, since insulin is involved in cholesterol damage. There is evidence that lecithin and other phospholipids protect the body against fatty degeneration.
Eggs for several reasons might actively protect against the formation of cholesterol deposits. One of the men who discovered insulin, Best, later showed that choline (a component of lecithin) can prevent fatty degeneration of the liver. Very large doses of biotin cause experimental animals to develop fatty livers (developing into liver cancer). but this effect can be offset by feeding the animal another B vitamin. inositol. Some of these effects have been known for about half a century, but too many " health professionals" are still pretending that no valid data exist. Maybe we should start asking whether these " health professionals" have a valid existence.”
….
The Myth of Iodine Deficiency: An Interview with Dr. Ray Peat
Is iodine supplementation safe and, if not, is there a safe amount of supplemental iodine?
Dr. Peat: “A dosage of 150 mcg (micrograms, not milligrams, e.g., ug not mg) is a safe amount of iodine. There are excellent references describing the effect of a moderate iodine excess (even below a milligram per day) on the thyroid. An iodine deficiency can cause hypothyroidism (rare now), but so can an excess. Iodine deficiency is an unusual cause of hypothyroidism, except in a few places, like the mountains of Mexico and China, and the Andes.
“Most goiters now are from estrogen-like effects, but they used to be from iodine deficiency. Chronic excess iodine tends to cause thyroiditis, regardless of the gland’s size. The amounts used by Abraham and Flechas are much larger than this — very toxic doses, enough to cause severe thyroid problems.”
Is the Iodine Test Kit (from Dr. Abraham) valid and does it reveal thyroid deficiency?
“Guy Abraham and some of his followers claim that an iodine deficiency can be shown by the quick disappearance of a spot of iodine painted on the skin. The skin test of iodine deficiency is completely unscientific. Iodine is converted to colorless iodide by reductants, including vitamin C, glutathione, and thiosulphate. “G. Abraham’s Iodine Test Kit contains iodine overdose pills. The test is completely irrational. It implies that the body should be saturated with iodine.”
Is there a rational way to determine iodine deficiency or excess?
“It’s easy to recognize a chronic iodine deficiency, because it causes the thyroid gland to enlarge. Goiters can be caused in various ways, for example by being exposed to various goitrogens, including excess iodine, or by excessive estrogen and deficient progesterone, as well as by an iodine deficiency. “However, a chronic excess of iodine is harder to recognize, because it can produce a variety of degenerative changes. Measurement of the average daily iodine intake or excretion in the urine would be needed to confirm an excess. High iodine intake can suppress TSH, and since high TSH is pro-inflammatory, the iodine can have some protective anti-inflammatory actions, but in the long run, the thyroid suppression becomes a problem.”
To Your Health – July 2008 by Lita Lee
Also:
Mary Shomon: Do you think the majority of people with hypothyroidism get too much or too little iodine? Should people with hypothyroidism add more iodine, like kelp, seaweeds, etc.?
Dr. Ray Peat: 30 years ago, it was found that people in the US were getting about ten times more iodine than they needed. In the mountains of Mexico and in the Andes, and in a few other remote places, iodine deficiency still exists. Kelp and other sources of excess iodine can suppress the thyroid, so they definitely shouldn’t be used to treat hypothyroidism.
https://www.functionalps.com/blog/2...ine-deficiency-an-interview-with-dr-ray-peat/