Diokine
Member
- Joined
- Mar 2, 2016
- Messages
- 624
I would definitely second the importance of the calcium-phosphorus ratio. The picture of metabolism that I see has calcium metabolism as one of the most important factors in whole body energy generation and good health. Using estrogen as an example, which has the action of shifting the ratio of intracellular calcium higher and has long term cellular restructuring effects. This increase in calcium swells the cell, causing it to take up water. These shifts in electrolytes also change the local electronic state, and this changes the way proteins assemble in the cell. Proteins like actin polymerize, forming long tube like structures which have incredible electrical properties themselves and which allow the cells to physically and electrically restructure quickly. My understanding is that the action of estrogen-like compounds modulates the rate of polymerization and changes the way reacts to stimulus or stress on a fundamental level. Calcium is a major player in this sense.
Let's look at a prototypical stress like endotoxin - the presence of LPS in the bloodstream is exceptionally irritating, so much so that we've developed resonant electrical structures in our cells that can detect it directly. In some sense it becomes difficult to distinguish between the direct toxicity of LPS and the inflammation caused by our response to it, but blocking some of the primary immune reactions like nitric oxide production is shown to reduce the toxic effects to cells. I think LPS causes direct injury to cell membranes and is very disruptive electrically, causing rapid actin depolymerization and an abrupt change in the potential of the cell. Instantly sodium and potassium are lost from the cell, and it takes up calcium and water.
Well in a situation less drastic than the example above, waterlogged cells in a bad environment are unable to generate proper energy flux to draw calcium out of the cell. Sodium is lost and the the production of energy drops further. Tissue in this state is not responding to thyroid hormone properly, and very little CO2 is being produced. This is a bad way for cells to go. Like I said in the previous post, it is the job of the kidneys (and adrenal system) to make sure cells are not in a bad environment. Again, calcium is a major player in this sense. Phosphorus also, in the form of phosphate, directly controls the rate of polymerization of actin. The other electrolytes are also important of course, as well as steroid solubility and antioxidant / oxidant ratios. The kidneys though, are incredibly important for maintaining these ratios, and my experience is that chronic smoking will effect the kidneys. Cigarette smoke has cadmium, which accumulates in the kideys - lots of other effects also.
Let's look at a prototypical stress like endotoxin - the presence of LPS in the bloodstream is exceptionally irritating, so much so that we've developed resonant electrical structures in our cells that can detect it directly. In some sense it becomes difficult to distinguish between the direct toxicity of LPS and the inflammation caused by our response to it, but blocking some of the primary immune reactions like nitric oxide production is shown to reduce the toxic effects to cells. I think LPS causes direct injury to cell membranes and is very disruptive electrically, causing rapid actin depolymerization and an abrupt change in the potential of the cell. Instantly sodium and potassium are lost from the cell, and it takes up calcium and water.
Well in a situation less drastic than the example above, waterlogged cells in a bad environment are unable to generate proper energy flux to draw calcium out of the cell. Sodium is lost and the the production of energy drops further. Tissue in this state is not responding to thyroid hormone properly, and very little CO2 is being produced. This is a bad way for cells to go. Like I said in the previous post, it is the job of the kidneys (and adrenal system) to make sure cells are not in a bad environment. Again, calcium is a major player in this sense. Phosphorus also, in the form of phosphate, directly controls the rate of polymerization of actin. The other electrolytes are also important of course, as well as steroid solubility and antioxidant / oxidant ratios. The kidneys though, are incredibly important for maintaining these ratios, and my experience is that chronic smoking will effect the kidneys. Cigarette smoke has cadmium, which accumulates in the kideys - lots of other effects also.