TRT At 22. At 24 I Started To Replace ALL Other Hormones

[thingsvarious]

Why are you taking florinef and what is your experience with it?

did you stop taking an ai?

Currently I take 0.25mg once per week anastrozole. Though will decide on my next blood test whether I cut that out completely.
Fludrocortisone is great because it is hydrocoortisone-sparing (symptom relief with lower dosages)

 

[b555]

Currently I take 0.25mg once per week anastrozole. Though will decide on my next blood test whether I cut that out completely.
Fludrocortisone is great because it is hydrocoortisone-sparing (symptom relief with lower dosages)

Did it raise your blood pressure? Was your aldosterone low?

 

[thingsvarious]

Did it raise your blood pressure? Was your aldosterone low?

Yes to both.
RR is now around 120-125, so perfect.

 

[b555]

Yes to both.
RR is now around 120-125, so perfect.

Thanks i considered florinef, my bp is normal to slightly elevated at 130/80, aldosterone is low, serum sodium low

 

[Broco6679]

Thanks i considered florinef, my bp is normal to slightly elevated at 130/80, aldosterone is low, serum sodium low

Is that alongside TRT?

 

[b555]

Is that alongside TRT?

Yes but been taking a break from trt for several weeks

 

[Broco6679]

Yes but been taking a break from trt for several weeks

Any reason why you're taking a break?
All my adrenal hormones were tanked on trt too - cortisol, dhea, prog, preg, aldosterone, etc, which is why I stopped myself.

 

[b555]

Any reason why you're taking a break?
All my adrenal hormones were tanked on trt too - cortisol, dhea, prog, preg, aldosterone, etc, which is why I stopped myself.

My cortisol is surprisingly decent but dhea, preg, prog, aldosterone have always been low. Trt didnt seem to lower them.
I stopped trt due to a supply issue, but i plan on starting soon. I also take preg and dhea 5mg, and was considering .o5 florinef


What are you taking now?

 

[Broco6679]

My cortisol is surprisingly decent but dhea, preg, prog, aldosterone have always been low. Trt didnt seem to lower them.
I stopped trt due to a supply issue, but i plan on starting soon. I also take preg and dhea 5mg, and was considering .o5 florinef


What are you taking now?

Weird that cortisol still hung on but the others dropped. What dose of preg were you taking?
I don't take anything other than thyroid and dhea now, but still figuring the former out; might add in low dose hydrocortisone at some point soon. Once those are dialed in I'll consider restarting testosterone, but if I feel good I won't bother.

 

[thingsvarious]

Weird that cortisol still hung on but the others dropped. What dose of preg were you taking?
I don't take anything other than thyroid and dhea now, but still figuring the former out; might add in low dose hydrocortisone at some point soon. Once those are dialed in I'll consider restarting testosterone, but if I feel good I won't bother.

Simply feeling "good" is not the goal, but you seem like you know what you are doing. Also adding in HC without adequate anabolic hormones (IGF1, testo) down the line is a recipe for disaster (depending on the dosage of course)

 

[b555]

Weird that cortisol still hung on but the others dropped. What dose of preg were you taking?
I don't take anything other than thyroid and dhea now, but still figuring the former out; might add in low dose hydrocortisone at some point soon. Once those are dialed in I'll consider restarting testosterone, but if I feel good I won't bother.

50mg

@thingsvarious i have been doing similar experiments with tons of different hormones for 15 years. I cant say anything had a big effect on me other than dht
Iam very interested in your experience and thread on this,

 

[thingsvarious]

50mg

@thingsvarious i have been doing similar experiments with tons of different hormones for 15 years. I cant say anything had a big effect on me other than dht
Iam very interested in your experience and thread on this,

Weird that DHT seemed to make a difference. I didn´t notice anything from adding/withdrawing dutasteride 1x/w

 

[thingsvarious]

50mg

@thingsvarious i have been doing similar experiments with tons of different hormones for 15 years. I cant say anything had a big effect on me other than dht
Iam very interested in your experience and thread on this,

Just curious, why are you sure that DHT made a difference and it wasn´t something else?

 

[b555]

Just curious, why are you sure that DHT made a difference and it wasn´t something else?

No I can never be certain. I am only speculating it made a big difference, I would have to run the experiment multiple times

 

[PhoenixGaia]

Okay no offense but I would never want you to be my doctor. If you're trying all these random potentially very dangerous things on your own because you just think it's right, I can't imagine the things you'd prescribe to me.

Damn I'd be so glad to have this dude hahah

 

[PhoenixGaia]

I am a medical student in my last year. For a few years I have been replacing ALL of my hormones. It started out with just TRT at 22. Then I found out that all my other hormones are low as well.

In early twenties my life was starting to go down the gutter. My life started to fall apart in every domain. I started multiple hormone replacement. Whereas before my life was a nightmare, it has been a dream ever since. I have been doing this for some years now.

My question.As I am in my mid twenties, do you think this is sustainable for decades (see below)? Will my healthspan increase or decrease because of it? I am new to this group but I have been lurking for some time and found some great info. So I´d be curious what some experienced and qualified guys think.


You can´t outdrug/outbiohack/outlifestyle a bad hormonal profile.

What I take. YEARS of trial and error to device this protocol

Everyone is different, but the target range I aim for is in the upper tertile of the youthful reference range. Just falling somewhere within the reference range is not “optimal”. The reference range covers 95% of the population. Certainly more than 5% of the population have hormones bad enough to warrant intervention.

• TRT: Test Cyp (50mg subQ 2x/week), HcG (250iu subQ 2x/week), anastrozole (0.25mg 1x/week), dutasteride 0.5mg 1x/week (as my androgens are high I don´t need the DHT).
• cortisol: cortisone acetate (20mg/d HC equivalent) (split into 4 daily doses)
• thyroid: 1.25 grains NDT + 6.25mcg T3 (a few hours later in the day)
• GH: 1iu genotropin pfizer (aiming for IGF1 of 250) prebed
• fludrocortisone 01.mg/d morning
• melatonin: 0.25mg sublingual prebed

Other stuff I do: keto/paleo, HIIT, weekly rapamycin, a bunch of supplements (all of them together less worth than a slight alteration in hormones), some exercise every day, sleep around 6.5h (wake up refreshed without alarm -before HRT I needed 8+).

Before hormone replacement I was trying out every nootropic under the sun (modafinil, caffeine, shitty racetams, small doses of MTP, ephedrine). Now I don´t need any (sometimes a little nicotine gum while studying). My cognition is now almost always sharp, no brain fog, great energy, motivated. The combo of good sleep + cardio + keto + good hormones is much healthier and more sustainable than any stims/nootropics. Too bad that so many people focus just on supps and nootropics.

I do everyhing mostly myself because many (not all) endocrinologists are ***t. Once I found what works, taking all these hormones takes less than 5min per day and no thought whatsoever. Tiny price for a huge prize.

I am supervised by doctors, but if I took what they prescribed, massive potential wellbeing/performance/health would be left behind (stupid tradeoff for a small risk). They´d treat my thyroid with just T4. They´d use 30mg HC for adrenals (way too high -out of fear for a potential adrenal crisis. SMFH.). Testogel for sex hormones, (skin cream very bad for DHT), because it is much more convenient then injections. No AI. No growth hormone, because “it is bad for cancer” (SMFH even more). So in summary they´d be replacing every single hypothalamic axis suoptimally.

I run extensive blood tests.

I wrote about my experience here.

My goal: to find a great balance between performance/wellbeing and health/longevity.

My question. I am new to this group but I have been lurking for some time and found some great info. So I´d be curious what you guys think. As I am in my mid twenties, do you think this is sustainable for decades? Will my healthspan increase or decrease because of it?

If you have any questions hit me up.

Do you respond here? If so, may I ask why use fludrocortisone and not cortisone alone?

 

[thingsvarious]

Do you respond here? If so, may I ask why use fludrocortisone and not cortisone alone?

I am not too active on here but every now and again yes :)
Because fludrocortisone is cortisol-sparing, allowing me to use a lower dose of glucocorticoids which is the lesser evil of the additional risks associated with fludrocortisone

 

[Ihor]

I am not too active on here but every now and again yes :)
Because fludrocortisone is cortisol-sparing, allowing me to use a lower dose of glucocorticoids which is the lesser evil of the additional risks associated with fludrocortisone

What does "cortisol-sparing" mean, is it something that happening in the context of low sodium/aldosterone? Or if the sodium/aldosterone levels are normal, then you can also take fludrocortisone and get this "cortisol-sparing" effect?

 

[TheBeard]

Transdermal test is ***t. Read my guide about male sex hormone treatment.

I guess I skipped that part.
Can you elaborate on why you think this is?

Testosterone cream applied to the scrotum has the advantage to:

1) avoid injecting PUFA
2) avoid local inflammation from injection
3) spike DHT
4) allow for highly stable blood levels with twice a day application
5) bring testosterone levels easily way past the top of the range if desired with very little quantity applied to the scrotum.

 

[Andman]

I guess I skipped that part.
Can you elaborate on why you think this is?

Testosterone cream applied to the scrotum has the advantage to:

1) avoid injecting PUFA
2) avoid local inflammation from injection
3) spike DHT
4) allow for highly stable blood levels with twice a day application
5) bring testosterone levels easily way past the top of the range if desired with very little quantity applied to the scrotum.

this, not seeing any disadvantages (maybe the risks inherent to DMSO, although pretty sure most oil bases are worse esp long term)