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I don't know what makes sense long term with vit C supplementation in general for everyone, but it sure makes sense to me if you take big doses when you are fighting a cold, especially since you've had such good experience with vit C. I really like your posts, and hope you'll keep posting.. This stuff has me feeling worried everytime I take my vitamin C and that's not cool because I have had one of the worst colds and yet I hear in my head "no one needs mega doses" despite everything I have read to the contrary when you are battling infectious disease.
This seems to me like a useful part of a general discussion about vit C.I'm not denying the positive side, I'm wondering if there's a price to it.
MAAGA.
Interesting. All I know is Vitamin C has helped my anxiety. I feel bad for all the people with bad anxiety who are too afraid to try higher doses.- Bimodal Effects of Megadose Vitamin C on Adrenal Steroid Production in Man
"[..]each subject received two 500 mg vitamin C tablets q 6 h until the end of the study (days 3 to 10)."
"All the subjects tolerated the vitamin C dose (4 g/day) well. Serum ascorbate levels were 2.5 times higher during vitamin C ingestion than in the control period (1.82 ± 0.18 vs. 4.42 ± 0.29 mg/dl, p < 0.001)."
"Although ingestion of vitamin C did not alter the normal pattern of diurnal variation of plasma cortisol levels, it significantly lowered mean plasma cortisol levels at 0400, 0800, 1600, and 2000 hours (p < 0.05). Moreover, a significant decrease in the overall 24-hour plasma cortisol curve during vitamin C ingestion compared to the control period was observed (p < 0.02). TABLE 1 [one] demonstrates that there was a reduction in the maximum daily cortisol levels during vitamin C ingestion (p < 0.05) with a reciprocal increase of concomitant DHEA levels in association with vitamin C ingestion (p < 0.001)."
"Our studies indicate that megadose vitamin C decreases the sensitivity but not the capacity of adrenal gland to respond to ACTH. The present findings are in support of our earlier work in vim, in that vitamin C in beef adrenal inhibited 21-hydroxylase[4] and shifted the ACTH dose-response curve of corticosterone in rat adrenal to the right.[5] It is tempting to postulate that with vitamin C ingestion there may be a partial blockage of 21-hydroxylase so that more substrate becomes available for the androgenic pathway. This blockage is incomplete since a higher ACTH dose reverses the abnormal cortisol response to the low dose. Additional studies are required to determine the long-term effect of ascorbic acid ingestion on the hypothalamic-pituitary-adrenal axis in young adults and older age groups."
- Becoming Stress Proof: The History Of Stress With Hans SelyeInteresting. All I know is Vitamin C has helped my anxiety. I feel bad for all the people with bad anxiety who are too afraid to try higher doses.
- Ascorbic acid deficiency in guinea pigs: contrasting effects of tissue ascorbic acid depletion and of associated inanition on status indices related to collagen and vitamin D