Many collagen supplements also supply calcium. Indirectly triggering synthesis isn't as likely to cause problems and is probably rate-limited by the body. That is, silica and MSM more likely supply depleted precursors than a constant on signal. Pregnenolone is probably also involved. Vitamin D + K and magnesium could always be added to buffer against problems."The total collagen content of the body increases with aging, and the stiffness of that collagen also increases. The total collagen content in cancer patients is higher than in people without cancer (Zimin, et al., 2010)."
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