whodathunkit
Member
- Joined
- May 6, 2016
- Messages
- 777
I'm wondering if anyone can tell me how (or if) Peat resolves his general antipathy towards acetylcholinesterase (AChE) inhibitors with his love of coffee/caffeine? I've been reading a lot and can't find anything about it. Only one article so far where he talks about AChE and how it's good for us and more is generally better, but nothing about coffee in that article.
I see a lot of discussion around here about the benefits of coffee as well as some of the drawbacks, but any drawbacks people experience are usually chalked up to not supporting metabolism properly with sugar or other nutrients, or to individual biochemical problems with it. Almost nothing is ever said about coffee's effect on AChE, which IMO is one of the biggest deals with it, since inhibition of AChE can allow too much ACh to build up, and ACh is excitotoxic.
Coffee doesn't give me the jitters any more, thanks (I think) to improvement in liver function and probably overall nutritional status. But even when taken with lots of sugar, milk, and gelatin, it can still give me what I call privately "ACh-Up-It-Head", which is a generally overstimulated, fuzzy, stupid feeling that I also call fogbrain, (although brain fog may mean something else to others). My cognition and recall are pretty bad and coffee can make them worse. Not always, but sometimes.
I've also seen threads where IMO people were clearly describing symptoms from too much ACh and probably not enough AChE after drinking coffee, but the symptoms were ascribed to cortisol or other stress hormones.
Granted, I don't understand that much about the biochemistry of it (not due to lack of trying to understand but primarily due to accursed fogbrain), but it seems oxymoronic to dislike things in general that can easily cause excitotoxicity and yet still love caffeine/coffee. Because it does seem quite easy to induce excitotoxic symptoms with it. I think I've been inducing episodes my whole life, for example.
Can anyone 'splain this conundrum to me so that I see the rationality of using coffee despite it being an AChE inhibitor? Using little words and maybe pitchers? :p
Seriously, it's a point of interest and any enlightenment would be greatly appreciated. :)
I see a lot of discussion around here about the benefits of coffee as well as some of the drawbacks, but any drawbacks people experience are usually chalked up to not supporting metabolism properly with sugar or other nutrients, or to individual biochemical problems with it. Almost nothing is ever said about coffee's effect on AChE, which IMO is one of the biggest deals with it, since inhibition of AChE can allow too much ACh to build up, and ACh is excitotoxic.
Coffee doesn't give me the jitters any more, thanks (I think) to improvement in liver function and probably overall nutritional status. But even when taken with lots of sugar, milk, and gelatin, it can still give me what I call privately "ACh-Up-It-Head", which is a generally overstimulated, fuzzy, stupid feeling that I also call fogbrain, (although brain fog may mean something else to others). My cognition and recall are pretty bad and coffee can make them worse. Not always, but sometimes.
I've also seen threads where IMO people were clearly describing symptoms from too much ACh and probably not enough AChE after drinking coffee, but the symptoms were ascribed to cortisol or other stress hormones.
Granted, I don't understand that much about the biochemistry of it (not due to lack of trying to understand but primarily due to accursed fogbrain), but it seems oxymoronic to dislike things in general that can easily cause excitotoxicity and yet still love caffeine/coffee. Because it does seem quite easy to induce excitotoxic symptoms with it. I think I've been inducing episodes my whole life, for example.
Can anyone 'splain this conundrum to me so that I see the rationality of using coffee despite it being an AChE inhibitor? Using little words and maybe pitchers? :p
Seriously, it's a point of interest and any enlightenment would be greatly appreciated. :)