dervmai
progress
Can long term cyproheptadine use cause histamine intolerance? My thinking is that long term use of cypro (2mg per day) over say the course of like 6 months, can cause adaptive changes to the h1 receptors. Since the antihistamines are blocking the histamines at the h1 receptor, could that some how decrease the amount of h1 receptors there are. Causing someone to become more sensitive to histamine due to a down regulation? I don't know if this is the mechanism of how anti histamines work. Would like some input on this thanks!