Amazoniac
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Hydrolyzed collagen (gelatin) decreases food efficiency and the bioavailability of high-quality protein in rats
"Gelatin and collagen hydrolysate have been shown to improve skin hydration, transepidermal water loss, elasticity, and skin barrier dysfunction 7, 8. Furthermore, they have been used to promote weight loss because studies have shown that gelatin can inhibit appetite and promote satiety 9, 10. However, the use of gelatin in a protein-restricted diets (like those before and after gastrointestinal tract surgery, chronic renal insufficiency treatment diets, and those aimed to promote weight loss 11, 12) could be a potential nutritional risk. Insufficient protein intake (in terms of both quantity and quality) inhibits endogenous metabolism of proteins, prolongs the inflammatory phase of the healing process, decreases fibroblast proliferation, angiogenesis and collagen synthesis, and impairs tissue repair 12. Therefore, the use of gelatin in a protein-deficient diet could slow patient recovery."
"The animals fed only gelatin as protein source lost body weight in a similar way to those fed the protein-free diet, as reported in other studies 22 , 23. This result can be explained by the low protein quality of gelatin since its deficiency in indispensable amino acids inhibits endogenous protein synthesis. Furthermore, there is evidence in the literature that rats reject diets deficient in indispensable amino acids. As a result, the food intake of the animals is lower than their energy requirements 24. This was confirmed in the present study as the G10 group rejected more than half (57.6%) of the diet offered. The low energy intake along with the deficiency in indispensable amino acids accelerated the protein malnutrition of the animals 25."
"The high protein digestibility of the diets (approximately 95%) indicates that gelatin did not influence casein digestibility. The absorption of the amino acids in gelatin is facilitated since it is a partially-hydrolyzed protein derived from collagen, and its digestibility is comparable to that of casein 3 , 21. Therefore, it can be concluded that protein digestibility did not influence the decrease in protein efficiency in the casein/gelatin mixture."
"Considering that the casein/gelatin mixture (4:1 of protein content) has sufficient indispensable amino acid content, as well as high digestibility, this mixture could be expected to have protein quality close to that of casein. However, this study showed that gelatin negatively influenced the protein quality of the casein/gelatin mixture."
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"In the present study, using casein and gelatin mixtures of (20% of the protein content), it was observed that gelatin decreases the efficiency of a high-quality protein in protein-restricted diets. This finding suggests that in some clinical practices, mainly in situations that involve protein catabolism, gelatin, or partially-hydrolyzed collagen could eventually worsen the catabolic status and thus slow patient recovery. Moreover, in cases of high rate of catabolism, such as major burns, cancer, and malnutrition, special attention to the supplements prescription is suggested because these products can have gelatin as source of protein or amino acids."
"Gelatin interferes with protein efficiency of high-quality protein. This influence depends on the gelatin concentration in the mixtures and the amount of protein in the diet. When there is low protein intake, gelatin decreases food efficiency and the bioavailability of high-quality protein."
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Experimental models of malnutrition and its effect on skin trophism
"The malnourished animals in the gelatin group [(5% casein + 15% gelatin) vs (20% casein)] experienced weight loss and stunted growth; their skin was thinner and more fragile; they were lethargic and experienced hair loss."
"After a 30-day period, mean epidermal thick ness in the well-nourished group was statistically similar to that of the animals in the malnourished group; however, dermal thickness was significantly lower in the malnourished group compared to the well-nouris hed group (p<0.0001) (Figures 5A and 5B). Figures 5C and 5D show this difference in dermal thickness between the two groups from a histological point of view."
"The percentage of coll agen was higher in the group of well-nourished animals and this difference was statistically significant (p<0.003) (Figure 6A). In the qual itative histological analysis, the area of coll a gen was better organized in the well-nourished group compared to the malnourished group (Figures 6B and 6C)."
@tyw, I think that this might interest you.
"Gelatin and collagen hydrolysate have been shown to improve skin hydration, transepidermal water loss, elasticity, and skin barrier dysfunction 7, 8. Furthermore, they have been used to promote weight loss because studies have shown that gelatin can inhibit appetite and promote satiety 9, 10. However, the use of gelatin in a protein-restricted diets (like those before and after gastrointestinal tract surgery, chronic renal insufficiency treatment diets, and those aimed to promote weight loss 11, 12) could be a potential nutritional risk. Insufficient protein intake (in terms of both quantity and quality) inhibits endogenous metabolism of proteins, prolongs the inflammatory phase of the healing process, decreases fibroblast proliferation, angiogenesis and collagen synthesis, and impairs tissue repair 12. Therefore, the use of gelatin in a protein-deficient diet could slow patient recovery."
"The animals fed only gelatin as protein source lost body weight in a similar way to those fed the protein-free diet, as reported in other studies 22 , 23. This result can be explained by the low protein quality of gelatin since its deficiency in indispensable amino acids inhibits endogenous protein synthesis. Furthermore, there is evidence in the literature that rats reject diets deficient in indispensable amino acids. As a result, the food intake of the animals is lower than their energy requirements 24. This was confirmed in the present study as the G10 group rejected more than half (57.6%) of the diet offered. The low energy intake along with the deficiency in indispensable amino acids accelerated the protein malnutrition of the animals 25."
"The high protein digestibility of the diets (approximately 95%) indicates that gelatin did not influence casein digestibility. The absorption of the amino acids in gelatin is facilitated since it is a partially-hydrolyzed protein derived from collagen, and its digestibility is comparable to that of casein 3 , 21. Therefore, it can be concluded that protein digestibility did not influence the decrease in protein efficiency in the casein/gelatin mixture."
"Considering that the casein/gelatin mixture (4:1 of protein content) has sufficient indispensable amino acid content, as well as high digestibility, this mixture could be expected to have protein quality close to that of casein. However, this study showed that gelatin negatively influenced the protein quality of the casein/gelatin mixture."
?
"In the present study, using casein and gelatin mixtures of (20% of the protein content), it was observed that gelatin decreases the efficiency of a high-quality protein in protein-restricted diets. This finding suggests that in some clinical practices, mainly in situations that involve protein catabolism, gelatin, or partially-hydrolyzed collagen could eventually worsen the catabolic status and thus slow patient recovery. Moreover, in cases of high rate of catabolism, such as major burns, cancer, and malnutrition, special attention to the supplements prescription is suggested because these products can have gelatin as source of protein or amino acids."
"Gelatin interferes with protein efficiency of high-quality protein. This influence depends on the gelatin concentration in the mixtures and the amount of protein in the diet. When there is low protein intake, gelatin decreases food efficiency and the bioavailability of high-quality protein."
--
Experimental models of malnutrition and its effect on skin trophism
"The malnourished animals in the gelatin group [(5% casein + 15% gelatin) vs (20% casein)] experienced weight loss and stunted growth; their skin was thinner and more fragile; they were lethargic and experienced hair loss."
"After a 30-day period, mean epidermal thick ness in the well-nourished group was statistically similar to that of the animals in the malnourished group; however, dermal thickness was significantly lower in the malnourished group compared to the well-nouris hed group (p<0.0001) (Figures 5A and 5B). Figures 5C and 5D show this difference in dermal thickness between the two groups from a histological point of view."
"The percentage of coll agen was higher in the group of well-nourished animals and this difference was statistically significant (p<0.003) (Figure 6A). In the qual itative histological analysis, the area of coll a gen was better organized in the well-nourished group compared to the malnourished group (Figures 6B and 6C)."
@tyw, I think that this might interest you.