Head Injury

[Peatress]

@Peatress -My brother-in-law has Parkinson's (chemical injury to the brain?) and he has very positive things to say about infrared light. He has been using a large panel of red LEDs twice daily for about 7 weeks. The image in the article above may be misdirecting in that more lights may be needed. I am beginning to explore red light for Parkinson's here.

Thanks David. Unfortunately I've had to give up on red light because of bruising.

 

[Peatress]

Using red light again but at a distance that doesn't induce bruising.

 

[Peatress]

Disorders of sodium balance after brain injury

Disorders of sodium balance after brain injury

Sodium disturbances are common in patients with brain injury because of the major role that the central nervous system plays in the regulation of sodium an

academic.oup.com

Salt or sugar for your injured brain? A meta-analysis of randomised controlled trials of mannitol versus hypertonic sodium solutions to manage raised intracranial pressure in traumatic brain injury - Database of Abstracts of Reviews of Effects (DARE)

Cerebral salt wasting after traumatic brain injury: a review of the literature

https://link.springer.com/content/pdf/10.1186/s13049-015-0180-5.pdf?pdf=button

 

[Peatress]

Head injury information Directory (UK)

National Services | Services | Head injury information Directory (HIID)

Details for national brain injury clinical services, support services and rehabilitation services across Scotland.

www.hiid.org.uk

https://twitter.com/headinjuryinfo

 

[Peatress]

Taurine And Wound Healing

Thanks to the large-brained Flávio: The locally administreated taurine significantly increased wound tensile strength by decreasing the MDA and histamine levels and prevented the degranulation of the mast cells. These observations suggest that taurine may be useful on wound healing. Pubmed...

raypeatforum.com

 

[David PS]

Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy - PubMed

After tPBM, these ex-football players improved. Significant correlations of increased SN FC and CEN FC with specific cognitive tests and behavior/mood ratings, plus increased NAA in ACC support beneficial effects from tPBM.

pubmed.ncbi.nlm.nih.gov

 

[Peatress]

Thank you @David PS

 

[Peatress]

Lisuride - Liquid Lisuride For Lab/R&D

After many months of often fruitless searching and negotiations with chemical vendors from all over the world, I am pleased to finally announce the release of our Lisuride product. This is perhaps the most anticipated product we have ever released and it is for a good reason. The recent...

raypeatforum.com

 

[David PS]

Published: 07 March 2023

Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis - IOS Press

Background: Choline alphoscerate (alpha glyceryl phosphorylcholine, α-GPC) is a choline-containing phospholipid used as a medicine or nutraceutical to improve cognitive function impairment occurring in neurological conditions including adult-onset de

content.iospress.com

Conclusion:​

α-GPC alone or in combination with donepezil improved cognition, behavior, and functional outcomes among patients with neurological conditions associated with cerebrovascular injury.

 

[Peatress]

I think it was a mistake to rely on food alone for my vitamin c. I seem to need more than my diet can provide. Started supplementing LGS vitamin C today in addition to food sources.

Antioxidants - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

A study to assess antioxidant depletion in patients additionally showed that those with intracranial hemorrhage and head trauma had lower plasma levels of vitamin C than controls, and that its levels were significantly inversely correlated with the several outcomes of the disease (i.e., severity of the neurological impairment and diameter of the lesion).

 

[Peatress]

Role of vitamin D and calcium signaling in epidermal wound healing - PubMed

Vitamin D and calcium signaling are critical for the ability of epidermal and hair follicle stem cells to respond to wounding. Vitamin D deficiency with the accompanying decrease in calcium signaling can result in delayed and/or chronic wounds, a major cause of morbidity, loss of productivity...

pubmed.ncbi.nlm.nih.gov

 

[David PS]

Most people in the US are reported to be magnesium deficient.

Rapid recovery from major depression using magnesium treatment - PubMed

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person's life, sometimes to such an extent that suicide is attempted or results...

pubmed.ncbi.nlm.nih.gov

Abstract​

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person's life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study. Fortifying refined grain and drinking water with biologically available magnesium to pre-twentieth century levels is recommended.

 

[Peatress]

Thyroid function in severely traumatized patients with or without head injury - PubMed

The pattern of thyroid function changes following severe trauma was assessed prospectively in 35 patients during the first 5 days after injury. Patients were divided into 2 groups to evaluate the effect of head injury: group I, patients with severe head injury; group II, patients with multiple...

pubmed.ncbi.nlm.nih.gov

I don't understand why this would be the case

"The presence of severe head injury was associated with lower levels of TSH and free T3."

 

[Peatress]

Eddie's story - hypothyroidism and head injury - Pituitary Foundation

I was encouraged by Peter Lapsley’s confirmation that Patient Journeys do indeed help doctors to reach the correct diagnosis more quickly, and wish to offer my own experience in the hope of furthering that purpose.

www.pituitary.org.uk

The screening and management of pituitary dysfunction following traumatic brain injury in adults: British Neurotrauma Group guidance | Journal of Neurology, Neurosurgery & Psychiatry

 

[David PS]

Traumatic Brain Injury: Effects on the Endocrine System

Traumatic brain injury, also called TBI, is sudden damage to the brain. It happens when the head hits something violently or is hit again and again, or when an

academic.oup.com

 

[Peatress]

The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review - PubMed

Abundant evidence supports the pathologic role of AGEs in ageing and dermal wound healing and the effectiveness of possible therapeutic agents. More research is required to conclude its role in scar formation and scar therapy.

pubmed.ncbi.nlm.nih.gov

 

[Peatress]

Riding out the storm: sympathetic storming after traumatic brain injury - PubMed

Following acute multiple trauma, hypothalamic stimulation of the sympathetic nervous system and adrenal glands causes an increase in circulating corticoids and catecholamines, or a stress response. In individuals with severe traumatic brain injury or a Glasgow Coma Scale score of 3-8, this...

pubmed.ncbi.nlm.nih.gov

 

[Peatress]

Head injuries could be a risk factor for developing brain cancer

Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumour called a glioma.

www.ucl.ac.uk

Cancer: Disorder and Energy

New descriptive sentence from the article here

raypeat.com

 

[Peatress]

Folate stimulation of wound DNA synthesis - PubMed

Folate supplementation has a stimulatory effect on wound DNA synthesis, which would be expected to accelerate wound healing. Nutrition intake is essential for tissue repair by a mechanism that increases net protein deposition in the wound.

pubmed.ncbi.nlm.nih.gov

 

[Peatress]

Progesterone is being used to treat brain injuries, very successfully. It protects against inflammation, and in an early study, compared to placebo, lowered mortality by more than half. It's instructive to consider its anticholinergic role in the uterus, in relation to its brain protective effects. When the brain is poisoned by an organophosphate insecticide, which lowers the activity of cholinesterase, seizures are likely to occur, and treatment with progesterone can prevent those seizures, reversing the inhibition of the enzyme (and increasing the activity of cholinesterase in rats that weren't poisoned) (Joshi, et al., 2010). Similar effects of progesterone on cholinesterase occur in menstrually cycling women (Fairbrother, et al., 1989), implying that this is a general function of progesterone, not just something to protect pregnancy. Estrogen, with similar generality, decreases the activity of cholinesterase. DHEA, like progesterone, increases the activity of cholinesterase, and is brain protective (Aly, et al., 2011).

Brain trauma consistently leads to decreased activity of this enzyme (Östberg, et al., 2011; Donat, et al., 2007), causing the acetylcholine produced in the brain to accumulate, with many interesting consequences. In 1997, a group (Pike, et al.) created brain injuries in rats to test the idea that a cholinesterase inhibitor would improve their recovery and ability to move through a maze. They found instead that it reduced the cognitive ability of both the injured and normal rats. An anticholinergic drug, selegeline (deprenyl) that is used to treat Parkinson's disease and, informally, as a mood altering antiaging drug, was found by a different group (Zhu, et al., 2000) to improve cognitive recovery from brain injuries. Ray Peat