Please advise

[Morten]

I need an advise regarding aspirin as a possible lithium antagonist. My mothers doctor says those two substances can be taken together. My mother has been taken lithium for decades for her mental health, and recently she's been diagnosed with cancer near the nose. I Thought a protocol could be aspirin( 2 x 325 mg daily), and Idealabs pyrucet, 3 - 4 drops on the navel area for that cancer. I have not been able to find anything regarding lithium and aspirin....Hope someone has a clue.

 

[aliml]

Aspirin appears to be beneficial for patients taking lithium.

Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorder - PubMed

Low-dose aspirin produced a statistically significant duration-independent reduction in the relative risk of clinical deterioration in subjects on lithium, whereas other NSAIDs and glucocorticoids did not. These tentative findings could be tested on larger databases containing detailed...

pubmed.ncbi.nlm.nih.gov

Safety and Efficacy of Combined Low-Dose Lithium and Low-Dose Aspirin: A Pharmacological and Behavioral Proof-of-Concept Study in Rats - PubMed

Despite established efficacy in bipolar disorder patients, lithium (Li) therapy has serious side effects, particularly chronic kidney disease. We examined the safety and behavioral effects of combined chronic low-dose aspirin plus low-dose Li in rats to explore the toxicity and therapeutic...

pubmed.ncbi.nlm.nih.gov

Aspirin for recurrence prevention in bipolar disorder-Promising, yet clinically understudied? - PubMed

Aspirin for recurrence prevention in bipolar disorder-Promising, yet clinically understudied?

pubmed.ncbi.nlm.nih.gov

Low-Dose Aspirin Augments the Anti-Inflammatory Effects of Low-Dose Lithium in Lipopolysaccharide-Treated Rats - PubMed

Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood-disorders in general and of bipolar disorder in particular. The current study examined the effects of chronic low-dose aspirin and low-dose lithium (Li) treatment...

pubmed.ncbi.nlm.nih.gov

Indomethacin but not aspirin increases plasma lithium ion levels - PubMed

The pharmacokinetic drug interactions between lithium sulfate and the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin and aspirin were studied in ten normal female volunteers restricted to 150-mEq/day of sodium. Indomethacin decreased renal lithium ion elimination by 23% and caused a...

pubmed.ncbi.nlm.nih.gov

 

[GTW]

The form of lithium is a critical variable.
Carbonate and sulfate may have dangerously low therapeutic indices. Amines like lithium orotate not so?

 

[Morten]

The form of lithium is a critical variable.
Carbonate and sulfate may have dangerously low therapeutic indices. Amines like lithium orotate not so?

Hi GTW.

I´m danish, so I don't fully understand....Carbonate and sulfate, you mean lithium carbonate and lithium sulfate? Is that two different kinds?, if, then I must check it out. The last sentence I do not fully grasp:)

 

[GTW]

Lithium carbonate and lithium sulfate are two forms\lithium compounds.
Lithium orotate is commonly available nutritional supplement, often taken at 5-10 mg doses.

 

[Morten]

Lithium carbonate and lithium sulfate are two forms\lithium compounds.
Lithium orotate is commonly available nutritional supplement, often taken at 5-10 mg doses.

Ahhh, now I understand. Do you know anything about, which is the safest? Carbonate or Sulfate. In the studies above, they make no difference in the lithium type, it says only "Lithium"

 

[GTW]

Ahhh, now I understand. Do you know anything about, which is the safest? Carbonate or Sulfate. In the studies above, they make no difference in the lithium type, it says only "Lithium"

That's the problem.
Amine is safer because often effective at the 5-10 mg doses.

 

[GTW]

>LiOr is proposed to cross the blood–brain barrier and enter cells more readily than Li2CO3, which will theoretically allow for reduced dosage requirements and ameliorated toxicity concerns.

Lithium orotate: A superior option for lithium therapy?

Bipolar disorder (BD) poses a significant public health concern, with roughly one‐quarter of sufferers attempting suicide. BD is characterized by manic and depressive mood cycles, the recurrence of which can be effectively curtailed through lithium ...

www.ncbi.nlm.nih.gov

 

[GTW]

Note also that aspirin used in studies ref above, low dose <125 mg?

 

[Morten]

>LiOr is proposed to cross the blood–brain barrier and enter cells more readily than Li2CO3, which will theoretically allow for reduced dosage requirements and ameliorated toxicity concerns.

Lithium orotate: A superior option for lithium therapy?

Bipolar disorder (BD) poses a significant public health concern, with roughly one‐quarter of sufferers attempting suicide. BD is characterized by manic and depressive mood cycles, the recurrence of which can be effectively curtailed through lithium ...

www.ncbi.nlm.nih.gov

So the commenly available used Lithium Orotate is the one, which could cross the blood-brain barrier? I take two babyasp. every day 2 x 50 mg, and consider that dose for my mother as well, it will be under the 125 mg. Thanks for your service:))