johnwester130
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Impact of atrovastatin and perindopril on the hair cycle in rodent model – risk of drug induced alopecia in patients with heart disease
Impact of atrovastatin and perindopril on the hair cycle in rodent model – risk of drug induced alopecia in patients with heart disease
Perindopril belongs to ACE inhibitors and drug-induced hair loss occurs in 1-5% of treated patients. According to available data, it is observed both in adults and children.
Based on the course of the spontaneous and induced hair cycles the relationship between telogen effluvium and perindopril intake was proven. The hair loss evolved slowly during the experiment. There were only slight differences between tested and control groups during the first spontaneous and induced hair cycles. It was due to premature hair follicle involution not followed by the telogen synchronization. II and III induced and spontaneous hair cycles showed progression of the hair follicle destruction. The premature hair follicle involution was followed by the telogen synchronization and showed toxic effect of the drug responsible for the alopecia. Analysis of the induced and spontaneous hair cycles in time confirmed time related hair follicle destruction, leading to the chronic drug-induced alopecia
ACE inhibitors on zinc levels was also studied (19). During 9 weeks of experiment animals received 2 mg of captopril intraperitoneally. Afterwards zinc levels were determined in indicated tissues. The hair zinc concentration was significantly decreased. It confirmed the role of perindopril in zinc metabolism and in alopecia occurrence. Especially due to fact that, hair loss in rats is related to zinc deficiency (9).
CONCLUSIONS
Perindopril has also toxic effect on the hair follicle and is responsible for drug-induced alopecia. Observed telogen effluvium is chronic and associated with prolonged therapy. In rats clinical outcome is late and involve hair shedding on the lateral body sides.
Thank you
great find