Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Click Here if you want to upgrade your account
If you were able to post but cannot do so now, send an email to admin at raypeatforum dot com and include your username and we will fix that right up for you.
Yes... Psychobiotics and the Manipulation of Bacteria–Gut–Brain SignalsIs it possible for probiotics to affect brain serotonin? Serotonin can't cross the BBB from what I know.
One programme of research [23] investigated the effect of Bifidobacteria infantis on male Sprague–Dawley rats (n = 20) in the forced swim test, stress responses, inflammation, and monoaminergic activity. While there were no behavioural changes in swim test performance, there were significant increases of tryptophan, the serotonin precursor, in the plasma. There were also decreased concentrations of 5-hydroxyindoleacetic acid, the serotonin metabolite, in the brain. This was taken as evidence of reduced serotonergic turnover. Compared to vehicle-fed rats, blood from probiotic-fed rats exhibited reduced concentrations of the pro-inflammatory cytokines tumour necrosis factor-α, interleukin-6, and interferon-γ. These reductions jointly characterise a dampened pro-inflammatory response. This approach highlights the importance of examining physiological variables in psychobiotic research, as physiological changes were noted in the absence of significant behavioural changes. ...
Recent work [25] has also studied psychobiotic-induced changes in central neurotransmitter concentrations in vivo using magnetic resonance spectroscopy (MRS). Healthy adult male BALB/c mice (n = 28) were administered with either Lactobacillus rhamnosus JB-1 or a vehicle for 4 weeks. Probiotic-fed mice showed elevated concentrations of glutamate and glutamine, total N-acetyl aspartate + N-acetyl aspartyl glutamic acid (tNAA), and GABA. The authors interpreted tNAA changes as a marker of alterations in neural metabolism resulting from the intervention. Glutamate is the chief excitatory neurotransmitter in the central nervous system, and, to the best of our knowledge, this is the first demonstration that it is sensitive to probiotics. The implications of concurrent elevations in both glutamate and GABA for regional excitation-inhibition balance are currently unknown, but are suggestive of an overall metabolic increase. Furthermore, because GABA and glutamate have opposing effects on neural excitability, it is possible that the total psychobiotic effect may be occurring within a zero-sum framework. The researchers also conducted periodic MRS, finding differential rates of emergence for the effects. For example, NAA increased after 2 weeks of probiotics, an elevation that was sustained for the remainder of the supplementation, and which returned to baseline 4 weeks thereafter. Glutamate and glutamine levels also increased after 2 weeks, and then remained elevated for a further 6 weeks, including 4 weeks after the intervention. Finally, GABA concentrations were only elevated in the fourth week of the intervention, but not before or after. These results represent a crucial step towards determining emergence and longevity of effects. While the general consensus is that ingestion of probiotics results in transient, rather than permanent, colonisation of the gut [26], these findings suggest both that psychobiotics may have some long-term effects, and that the effects have differential longevity.
Interesting. Thanks for posting.
Might want to avoid:
- Green tea, cocoa, kola, banana, pomegranate. Cereals, parsley, thyme, celery and citrus fruits >Enterococcus
- Onions, capers, apples, broccoli, grapes and plums. >Bifidobacterium infantis
- Peach, plums and coffee >E. coli, Bifidobacterium sps
Table 2 -Types of dietary polyphenols present in various foods and the types of microorganisms those are responsible for the degradation.
You may want to look into Bacteriophages. I take one every other day or so.
Toxinless, Dan Wich's website, has a short instructional video that is pretty good, as well as a list of available phages.
I recall watching a PBS documentary, at least 20 years ago, saying that the USSR discovered the phages to combat the gram negative bacteria. Believe it or not, they'd collect sewage run-off from hospitals, find the phages there, and study them.
We in the western countries went the antibiotic route. I'm glad we have both; there may be a symbiosis there, as the video on Toxinless intimates.
I've been thinking about something really scary - what happens if you need strong pain killers or antibiotics in the future? Will there ever be a time where it won't precipitate SS again?
I'd be curious to know if anyone has any thoughts around this too... I might be looking a surgery soon and I am terrified of the idea of having to take pain meds. I am going to discuss this at length with my doctor and will report back any of my findings, but in the mean time, does anyone know if there are pain meds that don't effect serotonin levels?
I am also a religious food diary keeper now, so far the my fitness pal app is getting it done... Not sure if anyone else here is into keeping data like me and has found anything better, but open to suggestions