Jacob28
Member
That sounds promising, but, y'know, I've tried so much stuff and I'm just dissapointed with it and quite sceptical.
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Molybdenum seems to be important for water homeostasis in plants (and it seems to be linked to abscisic acid/vitamin A too):
Effects of molybdenum on water utilization, antioxidative defense system and osmotic-adjustment ability in winter wheat (Triticum aestivum) under drought stress - ScienceDirect
"The osmotic-adjustment products such as soluble protein, proline and soluble sugar were also increased by Mo application under PEG simulated drought stress, indicating that Mo improved the osmotic adjustment ability in wheat. It is hypothesized that Mo application might improve the drought tolerance of wheat by enhancing water utilization capability and the abilities of antioxidative defense and osmotic adjustment."
It seems like it is related to osmolytes utilization.
Interestingly, molybdenum content in kidney is high, probably demonstrating its importance wrt water homeostasis in mammals too.
@Amazoniac
Water restriction could induce the upregulation of the CYP3A4 enzyme in the liver.
This enzyme seems to be able to convert cholesterols into oxysterols (25-hydroxycholesterol and 4β-hydroxycholesterol).
Moreover, these oxysterols are known to be ligands for the Liver X Receptor (LXR). What is interesting is that the LXR seems to be involved in testosterone synthesis in testis:
Liver X Receptor: A Cardinal Target for Atherosclerosis and Beyond
"Initially, this receptor was identified in tissue obtained from a rat liver, with no known endogenous ligands, and was named LXR. Later, LXR was termed an ‘adopted’ nuclear receptor with the discovery of oxysterols as endogenous ligands for this receptor."Another hypothetical reasoning:
"The cardinal functions of the testis are testosterone production and spermatogenesis. Leydig and Sertoli cells are testicular cells. Leydig cells secrete testosterone, while Sertoli cells provide structural and nutritional support for developing germ cells.
Furthermore, Leydig cells express LXRα, while Sertoli cells LXRβ, whereas germ cells express both LXRs. LXRα regulates basal testosterone synthesis and is involved in the control of germ cell apoptosis. In contrast, LXRβ controls lipid metabolism in Sertoli cells by regulating cholesterol export, as well as germ cell proliferation. Moreover, both LXRs together regulate ligand-induced steroidogenesis, fatty acid metabolism and, surprisingly, the retinoic acid signaling pathway in the testis."
"Moreover, both LXRs together regulate ligand-induced steroidogenesis, fatty acid metabolism and, surprisingly, the retinoic acid signaling pathway in the testis."
- the enzyme CYP11A1, also called CYP450scc, is in charge of converting cholesterol: "P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones. " (wikipedia)
- It seems like the transcription factor NFAT5 could have a link with this enzyme, RNA-Seq analysis of high NaCl-induced gene expression:
- "Categories of NFAT5 Target Genes Upregulated after Adaptation to High NaCl, but Not after as Little as 24 h of High NaCl.
- Steroid hormones. Cyp11a1 protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones."
- NFAT5 is upregulated during water restriction.
Cut all supplements, don’t take any hormone supplements either. Basically your diabetic. Your dehydrated from the high blood sugar. And you have chronically high insulin from the high blood sugar so your insulin resistant. Basically you need to de stress, and all supplements and hormones can stress you. Eating small meals, eating fruit juice, calcium, getting sunlight (not too much), eating foods rich in b vitamins, all help being chronically high blood sugar down
I've already tried that...
There was a time when I didn't use no supps and I didn't feel any better.
I drink 0,5-1l of milk a day and eat lots of fruit, I add some sucrose.
I don't think if I have high blood sugar, my fasting glucose was at normal level.
I know de-stressing is the best thing to do, but is it enough?
And why T3 doesn't work? Is it because of my poor live function? ( my ALAT is - 51)
Or because of low cholesterol?
I'm confused.
I mean, aspirin does work, but it's not the effect I expect and it makes replenishing sugar levels even harder.
Yes, I have.
It doesn't work unfortunetely :/
Now I just try to simplify everything, eat lots of carbs mostly from fruit and esp more protein- I just realised that's the thing I'm still missing, I just eat too little protein(!)
Do you think 150g will be OK for me?
Or too much? I eat like 70-max.90 and often like 60g...
I guess I'm gonna eat 50-70g of lean meat with some gelatin, beef or fish and add 30g of aminoacid mix( valine, lysine, leucine, isoleucine, threonine, alanine, I read here that 30g of aminos= 70g of protein) so all essential.
Do you think it's a good idea?