I am familiar with dr constanini and his work he has done great things with thiamine. I just didn’t want to up the dose very high and feel even worse and I wasn’t sure of the cause of my symptoms. Thank youDerrick Lonsdale likes to recommend TTFD thiamine. People who have been under stress for a long time can have depleted/insufficient glutathione. TTFD some how depletes/uses glutathione so can make that situation worse. This happened to me; one capsule of TTFD gave me a headache that lasted for 36 hours. I didn't take a second capsule. Elliot Overton did a video about this issue and recommended thiamine hcl because that type of thiamine can actually improve glutathione status. My glutathione status normalized from taking thiamine hcl.
Paradoxical Reactions With TTFD: The Glutathione Connection - Hormones Matter
In order to work, thiamine hcl needs to be taken in higher doses because of the poor absorption rate through the small intestinal wall. I follow Dr. Costantini's protocol and take 1 gram, 2Xday. Seven days of taking this dose of oral thiamine hcl equals to one 100mg injection of thiamine hcl.
Dr. Costantini successfully treated thousands of Parkinson's Disease patients in Italy using high dose thiamine hcl. There's lots of helpful info on his site. Dr. Costantini said that a person shouldn't have negative effects from taking thiamine. But he used thiamine hcl exclusively.