Lonsdale said that folate/b12 often start to decline (like used up properly) after thiamine supplementation. And before that they are often high, so maybe your tolerance of folates improved after normalising thiamine.Thank you Sergey, very valuable info! As for now my digestion is pretty much Fixed (after almost 3 years of Ibs) except some food intolerances remain - bananas, legumes, whole grains, some nuts, so gonna avoid those. Going to stop thiamine for a few days and see what happens. It’s weird since I’ve tried methyl folate two years sho and it made me anxious And restless and caused my mind to race, but now I tolerate it well. Weird stuff. Also after starting ttfd I had milky urine and burning sensation after urinating which went away later. Oxalate dumping? Had routine urine exam and urine culture which which came back negative. Weird stuff. Cyanocobalamine did nothing. Have yet to try the other forms. Molybdenum caused some pretty intense detox symptoms which went away in a few weeks.
I think that all this is not just about normalising thiamine somewhere. It clearly plays a critical role, but we don’t understand the whole picture, and other factors are definitelly involved. Probably even those outside of cellular metabolism.
The more I read about it, the more I have a feeling that thiamine “fixes” something not related to actual thiamine metabolism.
It does have a significant impact on gut flora composition, even in fermentation studies, so its not only related to the immune system normalisation etc. There seem to be states of gut microbiome related to low thiamine levels, and those states are self perpetuating. Various bacterial species and fungi produce thiaminases which not only limit supply to our cells, but also, maybe even more importantly, create quite unhealthy gut engironment.