I've had auditory hallucinations for a little over a year and a half. They are absolutely disruptive to my peace of mind. Nobody should have to go through this and we should have had the answers by now. At least better medication and methods to deal with it. I used to have delusions and cognitive issues like brain fog. As of now, I only have auditory hallucinations and internal visual hallucinations where I see the faces behind the voices. They exist in visualizations where my mind is forced to create an image of them doing something or reacting to my thoughts. My voices can see, hear, smell, and even feel what I feel. They can track my mind's focus. If I focus on an itch on my knee, they can tell which knee it is and exactly what I felt and mimic the same thing even though my eyes were closed. You can imagine how bad it can get for every pleasurable activity like eating, watching tv etc.
I've read many of Haiduts, Hans, Travis, and others posts about schizophrenia, adrenochrome, niacin, histamine, brain energy, glucose metabolism, ATP, hormones etc. to try and piece together as much as possible. What I've decided to do is optimize glucose metabolism using pyrucet, B vitamins, and aspirin. ATP supplements following an article from selfdecode 33 Natural Ways to Improve Mitochondrial Function - SelfDecode Health . I also use cardenosine and energin. Despite conventional medicine's take on dopamine for this condition, I've found using tyrosine, lisuride, metergoline etc. does nothing to my hallucinations. There is no increase in voices and it's clear that this dopamine mechanism has to be very specific. Research shows it's a part of the associative striatum where high dopamine levels is linked to hallucinations. It's not the root of the problem and nuking all dopamine with antipsychotics is not the answer. I use pregnenolone, progesterone, dhea, and t3 as well for brain function. Estroban, iodine, panquinone, lapodin, camphosal, and oxidal are all being used.
Recently I've been looking into sublingual application as I read it can reach the lymphatic system and is better able to reach the brain from there. I keep the supplements in my mouth for at least 10 minutes which I read Haidut recommended. It's only my second day and I just started doing it for 10 minutes today. It may be placebo but they aren't able to watch me and their speaking and commenting is reduced. Noticed a strong difference with 500 mg pregnenolone and progesterone dissolved in tocovit. I do sublingual for all vitamins minerals and many idealab products.
My goal is to cure this condition. I hope to one day go into research and study it. I want to propose studies that can determine more about the metabolism of the brain regions being affected. The metabolites that are being increased or decreased as a result. What certain hormones, vitamins, minerals do to symptoms. Especially sublingual application. I'm going to use this forum to organize my understanding of the topic and share it with others.
Out of all the theories for auditory hallucinations, I'm inclined to believe in the glutamate hypothesis. There's more recent research showing it's responsible for the excitation of these neurons. There's loss of grey matter which should be going along with high glutamate and lower oxidative phosphorylation. Lactate levels are higher and ph is lower. This is favoring the production of lactate meaning an inefficiency in energy production. The fact that there are so many neurotransmitters said to be involved with this condition has to mean there's a deep issue on a fundamental level. I remember Haidut quoting Ray Peat saying the brains of schizophrenics is too tired to even develop cancer. On a fundamental level, there's low brain energy. That's why schizophrenia goes along with the negative symptoms which is cognitive issues besides hallucinations and delusions. This is more subjective but in the experience of myself and others estrogen and serotonin increase brain verbalization. I could be wrong but I think Peat had dreams that were excessively verbal that was said to be linked to high serotonin and estrogen by Haidut. I wonder if the verbalization of auditory hallucinations along with neurotransmitter dysregulation can also involve neurosteroid dysregulation. Could be why pregnenolone and progesterone sublingually seemed to do something very noticeable.
I will be doing TMS and fmri neurofeedback. Getting on a new antipsychotic soon. They aren't all bad and some have good effects. For example clozapine is found to raise pregnenolone and allopregnanolone. Will be posting studies about these and discuss them as well.
A few things I noticed in my experience with the voices.
1. They go away when I concentrate on a task. Music, games, reading, socializing, and playing an instrument removes them. What mechanism could this be? What neurotransmitter changes are taking place? Why hasn't this been studied and become an idea for medications once the mechanism is figured out? Maybe it's there and I just haven't found it yet.
2. The voices are always negative and invasive with just a few being complete angels. I read of someone having completely positive voices. I have conscious control of their actions to some level. I can command them to do things. I used to torture them for torturing me and they would cry and suffer. What's the cause of this? Why are the voices for most people always negative and trying to irritate the individual?
My voices have clear names and personalities with distinct voices. It's very complex. They can surprise me at times with the complexity of their statements. They once told me to take their spaceship to mars. Meaning provide them an experience. They wanted me to be with women so they can feel and see everything. Very tough living with this. Can only imagine for many other people.
3. They are always mimicking me. From eating to yawning to dancing. They do everything I do. If I chew on food, they chew like a horse while saying how it tastes so good. What's being activated there is beyond me. My question is how do they know everything I'm doing? This has to be separate from the brain regions in auditory hallucinations. There has to be some hijacking of the thalamus and other regions involved with sensation and perception.
4. The images are very complex and instantaneous. The amount of brain activity makes it hard for me to believe that my brain is actually tired. It's a lot of work showing me these images where they are doing all these different things in response to what I'm doing. How does it have the energy for all of this? What's the energy efficiency in driving these processes?
Anyways, this is roughly what I've noticed and learned about auditory hallucinations so far. Hope this was interesting.
I've read many of Haiduts, Hans, Travis, and others posts about schizophrenia, adrenochrome, niacin, histamine, brain energy, glucose metabolism, ATP, hormones etc. to try and piece together as much as possible. What I've decided to do is optimize glucose metabolism using pyrucet, B vitamins, and aspirin. ATP supplements following an article from selfdecode 33 Natural Ways to Improve Mitochondrial Function - SelfDecode Health . I also use cardenosine and energin. Despite conventional medicine's take on dopamine for this condition, I've found using tyrosine, lisuride, metergoline etc. does nothing to my hallucinations. There is no increase in voices and it's clear that this dopamine mechanism has to be very specific. Research shows it's a part of the associative striatum where high dopamine levels is linked to hallucinations. It's not the root of the problem and nuking all dopamine with antipsychotics is not the answer. I use pregnenolone, progesterone, dhea, and t3 as well for brain function. Estroban, iodine, panquinone, lapodin, camphosal, and oxidal are all being used.
Recently I've been looking into sublingual application as I read it can reach the lymphatic system and is better able to reach the brain from there. I keep the supplements in my mouth for at least 10 minutes which I read Haidut recommended. It's only my second day and I just started doing it for 10 minutes today. It may be placebo but they aren't able to watch me and their speaking and commenting is reduced. Noticed a strong difference with 500 mg pregnenolone and progesterone dissolved in tocovit. I do sublingual for all vitamins minerals and many idealab products.
My goal is to cure this condition. I hope to one day go into research and study it. I want to propose studies that can determine more about the metabolism of the brain regions being affected. The metabolites that are being increased or decreased as a result. What certain hormones, vitamins, minerals do to symptoms. Especially sublingual application. I'm going to use this forum to organize my understanding of the topic and share it with others.
Out of all the theories for auditory hallucinations, I'm inclined to believe in the glutamate hypothesis. There's more recent research showing it's responsible for the excitation of these neurons. There's loss of grey matter which should be going along with high glutamate and lower oxidative phosphorylation. Lactate levels are higher and ph is lower. This is favoring the production of lactate meaning an inefficiency in energy production. The fact that there are so many neurotransmitters said to be involved with this condition has to mean there's a deep issue on a fundamental level. I remember Haidut quoting Ray Peat saying the brains of schizophrenics is too tired to even develop cancer. On a fundamental level, there's low brain energy. That's why schizophrenia goes along with the negative symptoms which is cognitive issues besides hallucinations and delusions. This is more subjective but in the experience of myself and others estrogen and serotonin increase brain verbalization. I could be wrong but I think Peat had dreams that were excessively verbal that was said to be linked to high serotonin and estrogen by Haidut. I wonder if the verbalization of auditory hallucinations along with neurotransmitter dysregulation can also involve neurosteroid dysregulation. Could be why pregnenolone and progesterone sublingually seemed to do something very noticeable.
I will be doing TMS and fmri neurofeedback. Getting on a new antipsychotic soon. They aren't all bad and some have good effects. For example clozapine is found to raise pregnenolone and allopregnanolone. Will be posting studies about these and discuss them as well.
A few things I noticed in my experience with the voices.
1. They go away when I concentrate on a task. Music, games, reading, socializing, and playing an instrument removes them. What mechanism could this be? What neurotransmitter changes are taking place? Why hasn't this been studied and become an idea for medications once the mechanism is figured out? Maybe it's there and I just haven't found it yet.
2. The voices are always negative and invasive with just a few being complete angels. I read of someone having completely positive voices. I have conscious control of their actions to some level. I can command them to do things. I used to torture them for torturing me and they would cry and suffer. What's the cause of this? Why are the voices for most people always negative and trying to irritate the individual?
My voices have clear names and personalities with distinct voices. It's very complex. They can surprise me at times with the complexity of their statements. They once told me to take their spaceship to mars. Meaning provide them an experience. They wanted me to be with women so they can feel and see everything. Very tough living with this. Can only imagine for many other people.
3. They are always mimicking me. From eating to yawning to dancing. They do everything I do. If I chew on food, they chew like a horse while saying how it tastes so good. What's being activated there is beyond me. My question is how do they know everything I'm doing? This has to be separate from the brain regions in auditory hallucinations. There has to be some hijacking of the thalamus and other regions involved with sensation and perception.
4. The images are very complex and instantaneous. The amount of brain activity makes it hard for me to believe that my brain is actually tired. It's a lot of work showing me these images where they are doing all these different things in response to what I'm doing. How does it have the energy for all of this? What's the energy efficiency in driving these processes?
Anyways, this is roughly what I've noticed and learned about auditory hallucinations so far. Hope this was interesting.
