It seems to be different from many supplements as it is a chemically produced dye that normally is not found in our physiology. Its not like taking B complex or thyroid or whatever that the body is used to deal with.MB like every supplement should be used with caution a lot of people blindly start taking very high doses of supplements without doing sufficient research or considering how their bodies might react.
Personally I have seen very positive results from MB but I have also seen instances where people have had very negative reactions. For example it can increase serotonin and if someone is already in a high serotonin state (which many people are) this can make things a lot worse.
The most I've ever taken of MB in one day is 20mg and when I do I also take something like cypro to counter the increase in serotonin that can occur.
I feel great on MB btw. 10-15mg feels amazing, gives me energy and I become so much better at everything I do. But so do amphetamines.